Epoch Biosciences, Inc.

Epoch Pharmaceuticals, Inc.

Elitech Holding B.v.

Michael J Singer

Igor V Kutyavin

Irina Aleksandrovna Afonina

Robert O Dempcy

Alexander A Gall

Nicolaas M J Vermeulen

Karen M Singer, Legal Representative

Nicolaas MJ Vermeulen

Software systems and methods for predicting the melting temperature (Tm) and other characteristics of oligonucleotides, including modified oligonucleotides. Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.

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Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.

Modified oligonucleotides for mismatch discrimination

Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo&lsqb;3,4-d&rsqb;pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.

Tm leveling methods

Growing community of inventors

Seattle, WA, United States of America

Michael J Singer