Viacyte, Inc.

Edwards Lifesciences Corporation

W. L. Gore & Associates, Inc.

Thoratec Corporation

Orqis Medical Corporation

Michael J Scott

Laura A Martinson

Chad Green

Vincent So

Rafael Pintor

William Charles Brunnett

August R Yambao

Faisal Kalam

Andrew Phung

Qinggang Zeng

Lawrence J Farhat

Harvey H Chen

Carey L Cristea

Craig McGreevy

Sara M Walls

Kevin W Zheng

Thomas H Chien

Gustavo Prado

Erik D Olson

Kevin Allen D'Amour

Derrick Johnson

Donald Koenig

Evert Kroon

Van Le Huynh

Giacomo Strollo

Mario Zamarripa

Robert A Pecor

Myron Howanec, Jr

Jerry L Jackman

Brian Eugene Brutcher

Louis A Campbell

Alan D Agulnick

Christopher R Folk

Grace Myong Kim

Greg Rusch

Rajesh Khanna

Visith Chung

David S Lin

Peng Norasing

Lauren Zambotti

Thomas Y Chien

Edwin T Ta

David Winer

Karmi Robison

Scott A Ritrovato

Timothy M Bruhn

Qiang (John) Zhang

Joseph Kakkassery

Faisai Kalam

Thomas Chien

Qinggang Zenq

A biocompatible membrane composite including a cell impermeable layer and a mitigation layer is provided. The cell impermeable layer is impervious to vascular ingrowth and prevents cellular contact from the host. Additionally, the mitigation layer includes solid features. In at least one embodiment, mitigation layer has therein bonded solid features. In some embodiments, the cell impermeable layer and the mitigation layer are intimately bonded or otherwise connected to each other to form a composite layer having a tight/open structure. A reinforcing component may optionally be positioned external to or within the biocompatible membrane composite to provide support to and prevent distortion. The biocompatible membrane composite may be used in or to form a device for encapsulating biological entities, including, but not limited to, pancreatic lineage type cells such as pancreatic progenitors.

Biocompatible membrane composite

Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes.

3-dimensional large capacity cell encapsulation device assembly

Systems of quickly and easily implanting a quick-connect heart valve prosthesis during a surgical procedure are provided. The heart valve may include a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A system and method for deployment includes an integrated handle shaft and balloon catheter. A safety member disposed between the balloon catheter and handle shaft prevents premature catheter advancement prior to heart valve placement at the annulus, and also may prevent premature balloon inflation prior to full catheter advancement.

Expandable prosthetic heart valve safety systems

Disclosed are cell encapsulation devices and methods for transplanting cells, such as pancreatic endoderm cells, into a host. In some examples, a cell encapsulation can comprise a lumen configured to receive cells therein, a cell-excluding membrane, where the lumen is internal to the cell-excluding membrane, and a non-woven fabric layer external to the cell-excluding membrane, where the non-woven fabric layer and the cell-excluding membrane comprise perforations. The device can further comprise a woven mesh external to the non-woven fabric layer, where the non-woven fabric layer provides protection to the cell-excluding membrane from direct contact with the woven mesh.

PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof

A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the frame attached thereto. The frame may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes an integrated handle shaft and balloon catheter. A valve holder is stored with the heart valve and the handle shaft easily attaches thereto to improve valve preparation steps.

Methods for rapidly deployable surgical heart valves

Embodiments herein describe tools and instruments for holding, transferring, delivering, deploying an implantable device and methods and means of aseptically storing and shipping the implantable device including but not limited to a device case for protecting, housing and filling the device, a surgical sizer for preparing the implantable site, a deployer for transferring the implantable device from the device case and delivering or deploying the implantable device at the prepared implantable site.

Tools and instruments for use with implantable encapsulation devices

Methods of quickly and easily implanting a quick-connect heart valve prosthesis during a surgical procedure are provided. The heart valve may include a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A system and method for deployment includes an integrated handle shaft and balloon catheter. A safety member disposed between the balloon catheter and handle shaft prevents premature catheter advancement prior to heart valve placement at the annulus, and also may prevent premature balloon inflation prior to full catheter advancement.

Methods of safely expanding prosthetic heart valves

Disclosed are devices and methods for transplanting cells, such as pancreatic endoderm cells, into a host. The devices include a non-woven fabric external to a cell-excluding membrane, and the non-woven fabric and/or cell-excluding membrane can be perforated. Treatment of the host with immunosuppressive reagents, required to inhibit allograft rejection due to perforations in the cell delivery device, does not compromise maturation or function of transplanted pancreatic endoderm cells.

Systems for rapidly deployable surgical heart valves

Disclosed herein are methods for cryopreserving, hibernation and room temperature storage of PEC aggregates, implantable semipermeable devices and the VC combination product.

Cryopreservation of encapsulated pancreatic endoderm cells

Safety systems for expansion of prosthetic heart valves

Growing community of inventors

San Diego, CA, United States of America

Michael J Scott