Amgen Inc.

Michael J Schmitt

Julio Cesar Medina

Jiwen Liu

Yingcai Wang

Jonathan B Houze

Zhihua Ma

Rajiv Sharma

Jinqian Liu

Zice Fu

Liusheng Zhu

Paul John Dransfield

Sean P Brown

Hilary Plake Beck

Todd J Kohn

Marc Vimolratana

Michelle Akerman

Wei Qiu

Ying Sun

Wang Shen

Jian Luo

Vatee Pattaropong

Zhongyu Wang

Jian Zhang

XianYun Jiao

SuJen Lai

Stephen J Shuttleworth

Daniel C H Lin

Jeffrey D Reagan

Qingge Xu

Xi Alan Huang

H Lucy Tang

Frank Kayser

Xiaoqi Chen

Daqing Sun

Jeffrey Thomas Mihalic

Xuelei Yan

David John Kopecky

Michael G Johnson

Yosup Rew

Felix Gonzalez Lopez De Turiso

Brian M Fox

Michael D Bartberger

Xiaodong Wang

John Eksterowicz

Jason A Duquette

Ana Zurisadai Gonzalez Buenrostro

Julie Anne Heath

Jeffrey Deignan

Richard V Connors

Steven H Olson

Darin J Gustin

Zhihong Li

Joel McIntosh

Jiasheng Fu

Xian Yun Jiao

Yihong Li

Philip M Roveto

Malgorzata Wanska

Christine Weathers

Jinqain Liu

Lucy H Tang

The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Heterocyclic GPR40 modulators

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Benzo-fused compounds for use in treating metabolic disorders

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ&#x2014;L&#x2014;P&#x2014;L&#x2014;M&#x2014;X&#x2014;L&#x2014;Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L, L, M, X, L, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders

Substituted biphenyl GPR40 modulators

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Asthma and allergic inflammation modulators

The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and Rhas the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders

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San Francisco, CA, United States of America

Michael J Schmitt