University of California

Other

The Boeing Company

Centre National De La Recherche Scientifique

University of Michigan

The Scripps Research Institute

Université Montpellier 2 Sciences Et Techniques

Ecole Nationale Superieure De Chimie De Montpellier

Michael J Sailor

Yang Yang Li

Keiki-Pua S Dancil

Sangeeta N Bhatia

William Freeman

Lingyun Cheng

Boyce E Collins

Frederique Cunin

Jamie R Link

M Reza Ghadiri

Shawn O Meade

Kianoush Motesharei

Jason Dorvee

Shang-Yi Lin

Jeffrey S Sakamoto

Mark Henry Tuszynski

Claudia Pacholski

Austin Derfus

Yacov M Koffler

Anne M Ruminski

Vincent V Doan

Jinyoung Kang

Gaurav Abbi

Gordon M Miskelly

Emily Anglin

Brian H King

Vicki I Chin

Byungji Kim

Jonathan Zuidema

Kendell M Pawelec

Ting Gao

Jun Gao

Frederic Victor Mikulec

William R Freeman

William C Trogler

Harold E Hager

Kenneth S Vecchio

William D Sherman

Christopher J Flaim

Sonia Edith Letant

Alain Morere

Marcel Garcia

Thomas Andrew Schmedake

Jean-Olivier Durand

Marie Maynadier

Magali Gary-Bobo

Ester Segal

Stephen Hedrick

Zhengtao Qin

Grace Credo

Julie Heinrich

Sadafumi Noda

Jeffery M Lauerhaas

Ji-Ho Park

Vijay S Kollengode

Nathan Trujillo

Joseph D Kirtland

Sara Alvarez

Benjamin Migliori

Lin Chao

Rebecca Campbell

Emilie Secret

Ulla Camilla Rang

Guarav Abbi

Jay L Snyder

Manuel M Orosco

Honglae Sohn

Rebecca M Calhoun

Timothy Kelly

Lou Gu

Michael P Schwartz

Laura Ruff

Magali Gary-bobo

Frédérique Cunin

Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.

Porous material with microscale features

This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.

Materials and methods for delivering compositions to selected tissues

The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic delivery of hydrophilic and lipophilic payloads by membrane fusion. The liposome coating can be further modified with targeting peptides or antibodies via covalent binding chemistry between the ligands and functionalized poly(ethylene glycol). The surface moieties can be transferred to the cellular membrane surface by fusogenic uptake. The composition of the disclosure can be applied in the treatment of diseases by delivering entrapped/encapsulated payloads.

Fusogenic liposome-coated porous silicon nanoparticles

A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.

Porous photonic crystals for drug delivery to the eye

A preferred embodiment biosensor is a multi-layer micro-porous thin film structure. Pores in a top layer of the micro-porous thin film structure are sized to accept a first molecule of interest. Pores in a second layer of the micro-porous thin film structure are smaller than the pores in the top layer and are sized to accept a second molecule of interest that is smaller than the first molecule of interest. The pores in the second layer are too small to accept the first molecule of interest. The pores in the top layer and the pores in the second layer are sized and arranged such that light reflected from the multi-layer micro-porous thin film structure produces multiple superimposed interference patterns that can be resolved. In preferred embodiments, the multi-layer micro-porous thin film structure is a porous silicon thin film multi-layer structure formed on a silicon substrate, such as a silicon wafer. Specific and nonspecific binding can be detected with biosensors of the invention. The position of peaks in the Fourier transform of the reflection spectrum and the shift in peak amplitudes can be used to determine the presence and quantity of targeted biological molecules of interest.

Multiple superimposed interface pattern porous microstructure multi layer biosensing method

Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (&#x3e;600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.

Functionalized porous silicon nanoparticles and use thereof in photodynamic therapy

A method of controlled in vivo drug delivery is provided. A porous silicon matrix having pores sized and configured to admit to trap and then release a predetermined molecular complex with a predetermined dose-time profile is selected. The matrix contains the predetermined molecular complex so that the predetermined molecular complex is disposed within the pores of the porous silicon matrix. The matrix is introduced into a human body. The drug releases according the dose-time profile. The introduction can be via transdermal introduction, intramuscular injection, intravenous introduction, surgical implantation, inhalation, and oral ingestion.

Methods for in vivo drug delivery with porous nanostructures

The invention provides nanostructure composite porous silicon and carbon materials, and also provides carbon nanofiber arrays having a photonic response in the form of films or particles. Composite materials or carbon nanofiber arrays of the invention are produced by a templating method of the invention, and the resultant nanomaterials have a predetermined photonic response determined by the pattern in the porous silicon template, which is determined by etching conditions for forming the porous silicon. Example nanostructures include rugate filters, single layer structures and double layer structures. In a preferred method of the invention, a carbon precursor is introduced into the pores of a porous silicon film. Carbon is then formed from the carbon precursor. In a preferred method of the invention, liquid carbon-containing polymer precursor is introduced into the pores of an porous silicon film The precursor is thermally polymerized to form a carbon-containing polymer in the pores of the porous silicon film, which is then thermally carbonized to produce the nano structured composite material. A carbon nanofiber array is obtained by dissolving the porous silicon. A carbon nanofiber array can be maintained as a film in liquid, and particles can be formed by drying the material.

Carbon and carbon/silicon composite nanostructured materials and casting formation method

The disclosure relates to immunizing agents and devices.

Luminescent porous silicon nanoparticles for targeted delivery and immunization

The invention concerns a particle having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features.

Optically encoded particles through porosity variation

Methods and systems of the invention can determine the identity and quantity of analytes in a vapor. In preferred methods, a porous optical film is exposed to vapor which contains analyte. The porous optical film is heated and its optical response is monitored during heating. An optical response observed via heating can determine the identity and/or quantity of the analyte. In preferred embodiments, optical response during a thermal pulse is compared to a database of sensor responses that are characteristic of various analytes. Preferred methods are conducted a relatively low temperatures, for example below about 200&#xb0; C. In preferred methods, a heating and cooling cycle produces a hysteresis curve in the optical response that is indicative of analytes. In preferred embodiments, a thermal reset pulse resets the porous optical film for later use and also provides an optical response that can be used for sensing.

Temperature response sensing and classification of analytes with porous optical films

Growing community of inventors

La Jolla, CA, United States of America

Michael J Sailor