3m Innovative Properties Company

Coley Pharmaceutical Group, Inc.

Graceway Pharmaceuticals, LLC

3m Innovation Properties Company

Michael J Rice

Bryon A Merrill

Kyle J Lindstrom

Philip D Heppner

Stephen L Crooks

John F Gerster

John W Mickelson

Gregory J Marszalek

Joshua R Wurst

Tushar A Kshirsagar

George W Griesgraber

Chad A Haraldson

Peter V Maye

Shri Niwas

Michael E Danielson

Sarah J Slania

Michael G Costello

John G Owens

Michael J Bulinski

Patrick L Coleman

Ai-Ping Wei

Mark A Tomai

David S Hays

Maureen Ann Kavanagh

Sarah A Strong

Matthew R Radmer

Ryan B Prince

Karl J Manske

Azim Alan Celebi

Hugues M H Martin

Joseph F Dellaria, Jr

Leslie J Charles

Sarah C Johannessen

Sarah C Slania

Sarah Johannessen

David J Squire

Hugues Martin

A working fluid that includes a fluorinated olefin compound represented by the following general formula (I): 

Fluorinated olefins as working fluids and methods of using same

A working fluid that includes a fluorinated olefin compound represented by the following general formula (I). In some embodiments, an apparatus for heat transfer is provided. The apparatus includes a device and a mechanism for transferring heat to or from the device. In some embodiments, a fire extinguishing composition is provided. In some embodiments, an apparatus for converting thermal energy into mechanical energy in a Rankine cycle is provided.

Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Alkoxy substituted imidazoquinolines

Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines

Imidazoquinolines and imidazonaphthyridines with a substituent containing a functional group, e.g., an amide, sulfonamide, urea, or heterocyclyl group, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Substituted imidazoquinolines and imidazonaphthyridines

Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a &#x2014;CH(&#x2014;X&#x2014;R)&#x2014; group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Chiral fused [1,2]imidazo[4,5-c] ring compounds

Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Aryloxy and arylalkyleneoxy substituted imidazoquinolines

Fused [1,2]imidazo[4,5-c] ring compounds, e.g., fused [1,2]imidazo[4,5-c]quinolines and [1,2]imidazo[4,5-c]naphthyridines, with a substituent, e.g., a substituted alkoxy substituent, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Substituted fused [1,2]imidazo[4,5-C] ring compounds and methods

Thiazoloquinoline and thiazolonaphthyridine compounds having an aryloxy or arylalkyleneoxy substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines

Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a &#x2014;CH(&#x2014;X&#x2014;R)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Chiral fused [1,2]imidazo[4,5-C] ring compounds

Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.

Intermediates for imidazonaphthyridines

Growing community of inventors

Oakdale, MN, United States of America

Michael J Rice