Gilead Sciences, Inc.

Michael J Postich

Choung U Kim

Lawrence R McGee

Matthew A Williams

John C Rohloff

Ernest J Prisbe

Lijun Zhang

Kenneth M Kent

John D Munger

Daphne E Kelly

Wenjin Yang

Norbert W Bischofberger

Steven H Krawczyk

Daphne E St John

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

Preparation of cyclohexene carboxylate derivatives

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

Preparation of carbocyclic compounds

Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositions are useful in raising antibodies against the thiepane haptens or the polypeptide. Labeled thiepanes of this invention are useful as diagnostic reagents.

Thiepane compounds

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San Mateo, CA, United States of America

Michael J Postich