Wyeth

Pharmacopeia Inc.

Michael J Ohlmeyer

Vidyadhar Madhav Paradkar

Adolph C Bohnstedt

Celia Kingsbury

Koc-Kan Ho

Nasrin Ansari

David J Diller

Irina Neagu

Jeffrey John Letourneau

Ray Anthony James

Haengsoon Park

Michelle Lee Morris

Christopher Mark Riviello

Rui Zhang

Patrick Anthony Jokiel

Ruiyan Liu

Chongwu Zhang

Jorge Quintero

Yingchun Lu

Jinqi Liu

James Robert Merritt

Marc Brescia

Ming You

Substituted pyridines, pyrimidines, pyrazines, pyridinones, pyrimidinones, pyrazinones and phenylacetamides useful in treating depression, stress and other disorders are disclosed. The compounds are of the formualae: Other embodiments are also disclosed.

Azinone and diazinone V3 inhibitors for depression and stress disorders

Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.

Ortho pyrrolidine, benzyl-substituted heterocycle CCR1 antagonists for autoimmune diseases and inflammation

The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II shown below, in which Q is selected from the group consisting of CX and nitrogen; and A is chosen from the group consisting of H, (C-C) alkyl, heteroaryl, and aryl: 

6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression

The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas: 

Purine and imidazopyridine derivatives for immunosuppression

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Plainsboro, NJ, United States of America

Michael J Ohlmeyer