University of Central Florida Research Foundation Inc

The Administrators of the Tulane Educational Fund

Tulane Educational Fund

Michael J Moore

Swaminathan Rajaraman

Charles Didier

Elaine Horn-Ranney

Jesse Ranney

Parastoo Khoshakhlagh

Julia Freitas Orrico

A three-dimensional (3D) microelectrode array for in vitro electrical and microfluidic interrogation of electrogenic cell constructs includes a substrate having a plurality of micro vias. A hypodermic microneedle is received within each micro via of a first subgroup of the plurality of micro vias and each has a length that exceeds the thickness of the substrate to form a hypodermic microneedle array on the top face of the substrate. Metallic traces are formed on the bottom face and interconnect the hypodermic microneedles. A culturing area is formed in the top face.

Three-dimensional microelectrode array having electrical and microfluidic interrogation of electrogenic cell constructs

Otologic materials and methods are provided. For example, a cell-adhesive, biodegradable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This hydrogel may promote vascular in-growth and epithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane perforation therapies.

Selectively polymerizable compositions and methods of use in vivo

Growing community of inventors

New Orleans, LA, United States of America

Michael J Moore