H. Lundbeck A/s

Michael J Mealy

Michael Harold Rock

Morten Jorgensen

Andre Faldt

Lone Munch Ringgaard

Heidi Lopez De Diego

Rene Holm

Nicholas Moore

Jorgen Brodersen

André Faldt

René Holm

Arne MØRK

Tine Bryan STENSBØL

Morten JØRGENSEN

Jørgen Brodersen

1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HTand 5-HTand may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

1-[2-(2,4-dimeihylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment

This disclosure relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulfanyl) -phenyl]piperazine or a pharmaceutically acceptable salt thereof. The process includes reacting compound II with compound III and compound IV in the presence of a solvent, a base and a palladium catalyst. R, R', X, and Xin the formulas above are defined in the Specification.

Process for preparing 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or pharmaceutically acceptable salt thereof

This disclosure relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or a salt thereof. The process includes reacting compound II with compound III and compound IV in the presence of a solvent, a base and a palladium catalyst. R, R', X, and Xin the formulas above are defined in the Specification.

Process for preparing 1-[2-(2,4-dimethylphenysulfanyl)-pheny]piperazine or pharmaceutically acceptable salt thereof

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Lejre, Denmark

Michael J Mealy