University of California

The University of Texas System

Geron Corporation

Other

Michael J McEachern

Michael D West

Jerry W Shay

Woodring E Wright

Elizabeth H Blackburn

Calvin B Harley

Homayoun Vaziri

Catherine M Strahl

Scott L Weinrich

Nam Woo Kim

Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.

Diagnostic methods for conditions associated with elevated cellular levels of telomerase activity

Methods of screening for compounds that derepress or increase telomerase

Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.

Telomerase activity assays for diagnosing pathogenic infections

Therapy and diagnosis of conditions related to telomere length and/or

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San Francisco, CA, United States of America

Michael J McEachern