Target Therapeutics, Inc.

Michael J Mariant

Thomas J Palermo

Ivan Sepetka

Son M Gia

David J Kupiecki

U Hiram Chee

Hong Doan

Pete Phong Pham

Gene L Samson

Erik T Engelson

Uriel Hiram Chee

Christopher G Ken

Nga Thi Van

Robert Hergenrother

Gregory E Mirigian

James C Peacock, Iii

Robert H Twyford, Jr

Roberto L Orellana

Jonathan A Laymon

A solderless sacrificial link between a detachable member which is placed at and is intended to remain at a desired site within the mammalian body and the core wire used to introduce the detachable member. The detachable member device may be one used to create emboli in the vascular system or may be of any other type deliverable into the human body and detached into an ionic aqueous environment, either for later removal or permanent placement.

System for detaching an occlusive device within a mammalian body using a solderless, electrolytically severable joint

This is an implantable vaso-occlusive device. It is a complex, helically wound coil comprised of a primary helically wound coil which is then wound into a specific secondary shape. The final shape upon deployment is in the approximate shape of an anatomical cavity. upon deployment, the device first fills the periphery of the cavity and then continues to infill the center. The device is a self-forming shape made from a pre-formed linear helically wound. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the vaso-occlusive device into appropriately shaped forms and annealing them.

Three dimensional in-filling vaso-occlusive coils

This invention is a surgical device. In particular, it is an implant which may be used to occlude vascular lumens, arteries, veins, aneurysms, vascular malformations, arteriovenous fistulas, or other cavities and lumens within a mammalian body. It is typically a substrate coil or braid to which a number of fibers have been secured using heat.

Vaso-occlusive devices with heat secured polymer fiber

Method for making an occlusive device

System for detaching an occlusive device within a body using a

This is a percutaneous medical device and related methods for its use. More particularly, it is a percutaneous catheter having ends which are interchangeably capable both of distal introduction into a delivery device lumen or body space and of proximal coupling to other medical devices.

Bi-directional catheter

Spiral vaso-occlusion coil

This is a solderless sacrificial link between a detachable member which is placed at and is intended to remain at a desired site within the mammalian body and the core wire used to introduce the detachable member. The detachable member device may be one used to create emboli in the vascular system or may be of any other type deliverable into the human body and detached into an ionic aqueous environment, either for later removal or permanent placement.

Solderless electrolytically severable joint for detachable devices

This is a surgical device that, in particular, is for forming a vasoocclusion or embolism. Typically, it is a helically wound coil in which the helix is wound in such a way as to have multiple axially offset, longitudinal or focal axes. Another important facet of the invention is the presence of small diameter secondary coil windings adjacent large diameter coil windings. The device is sufficiently flexible and small that it may be delivered to a site within the vasculature of the human body using a pusher and a catheter. The device is generally linear when within the catheter but relaxes to form the multi-focal form after delivery from the distal end of the catheter lumen. Various mechanical connections may also be used to discharge the inventive coil from its pusher. Similarly, the coil may be attached to a pusher using a sacrificial joint, which sacrificial joint is dissolved by imposition of a small voltage within the human body. The device may be used alone or in conjunction with other coils or with a fibrous thrombotic attachments or the substrate to localize subsequent infusion of tissue adhesives, other particulate embolization devices, or chemotherapeutic agents in abnormal blood vessels and tissues.

Embolic coils with offset helical and twisted helical shapes

A pusher-vasoocclusive coil assembly that is advanced through a catheter to a site within a vessel and is manipulated to detach the coil from the assembly. The coil has an affixed, proximally-extending wire that carries a ball on its proximal end and the pusher has an affixed, distally-extending wire that carries a ball on its distal end. The pusher and coil are coupled by placing the wires and balls in an overlapping interlocked position and enclosing the coupled assembly with a coaxial sleeve. The coil-pusher-sleeve assembly is positioned at the site and the sleeve is retracted to allow the balls to move radially relative to one another to disengage and uncouple the pusher and coil.

Detachable pusher-vasoocclusive coil assembly with interlocking coupling

Growing community of inventors

San Jose, CA, United States of America

Michael J Mariant