Amgen Inc.

Other

Michael J Malone

Nathan B Mantlo

Ulrike D Spohr

Jeffery A Zablocki

Jeffrey A Zablocki

Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Substituted pyridone compounds and methods of use

Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Substituted pyrimidine compounds and methods of use

For any specific, hard disk drive that occupies a specific logical position within a computer system, A Hard Disk Drive Selector is disclosed that permits the replacement of one physically distinct, permanently mounted hard disk drive for another physically distinct, permanently mounted hard disk drive within the specific logical position occupied. The Selector simultaneously controls the addressing traces, the control/command traces and the power supply connections to all hard disk drives connected to it. The selector operates by closing the address, command/control, and power circuits to the chosen hard disk drive while opening these circuits to all other hard disk drives connected to the selector. The choice of hard disk drive is made prior to &ldquo;booting&rdquo; the computer system and the choice is maintained until the computer system is turn off.

Hard disk drive selector

Substituted pyrimidinone and pyridone compounds and methods of use

Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

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Boulder, CO, United States of America

Michael J Malone