Other

Millennium Pharmaceuticals Limited

Biogen Ma Inc.

Millenium Pharmaceuticals, Inc.

Takeda Pharmaceutical Company Limited

Michael J Kaufman

Phuong Nguyen

Raymond D Skwierczynski

Nobel T Truong

Eric L Elliott

Quentin J McCubbin

Vaithianathan Palaniappan

Csanad M Varga

Debra L Mazaik

Abu J Ferdous

Peter Zawaneh

Sonja A Komar-Lay

Sonja A Komar

Peter N Zawaneh

Kalyan V Vasudevan

Cheuk-Yui Leung

Shyam B Karki

Ernest Quan

Phoung M Nguyen

Jinquan Dong

Sonja A Komar Lay

Quentin J Mccubbin

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Boronate ester compounds and pharmaceutical compositions thereof

A controlled release dosage form containing monomethyl fumarate, a compound that can be metabolized into monomethyl fumarate in vivo, or a pharmaceutically acceptable salt thereof or combinations thereof, wherein the monomethyl fumarate, a compound that can be metabolized into monomethyl fumarate in vivo, or a pharmaceutically acceptable salt thereof or combinations thereof is delivered to the subject. Also provided is a method of treating a disease or disorder (e.g., multiple sclerosis) by orally administering a controlled release dosage form containing monomethyl fumarate, a compound that can be metabolized into monomethyl fumarate in vivo, or a pharmaceutically acceptable salt thereof or combinations thereof, wherein the monomethyl fumarate, a compound that can be metabolized into monomethyl fumarate in vivo, or a pharmaceutically acceptable salt thereof or combinations thereof.

Controlled release dosage form for once daily administration of dimethyl fumarate

Contaminated water is chemically treated and aerated while being gravity fed through a trough. A series of slats are positioned in the trough to interrupt the flow and induce mixing and aeration. An array of aeration edges is removably installed over the slats. A holder for containing chemical treatment matter therein is positioned adjacent each slat. The aeration edges consist of upper and lower plates stacked one on top of the other. Each plate is provided with horizontal fingers extending in a direction downstream relative to the flow direction of the treated water. Each finger terminates in a baffle, which baffle is positioned substantially perpendicular to its finger.

Aeration and mixing trough

The invention is a water wheel supplying energy to a pump. The pump will typically be used to apply chemical treatments to the water stream. Some examples of chemicals to be added are acids or bases to bring the pH to an acceptable level, precipitation aids for suspending metal out of water, coagulants to aid in filtering dissolved solids out of water, flocculants to aid in filtering dissolved ions out of water, chlorine, or coloring to prevent growth of algae.

Water wheel for pumping chemical treatment into water stream

An apparatus for adapting a tool bar planting system to the front of an agricultural combine. The tool bar is secured to the front framework of the combine after the grain head has been removed. The tool bar includes folding extension arms that allow for various planting and transporting configurations. Planter seed units are attached to the tool bar and the extension units to complete the planting system. Seeds for the planter seed units are stored in the grain storage bin on the combine and delivered to the individual planter seed units by an air conveying system.

Tool bar planter system for combines

A pump for spraying an anti-freezing liquid on a conveyor belt exposed to freezing temperatures is controlled by an electric circuit containing a timer, a relay provided with a normally open switch, and a normally open thermostat that closes to start the timer when the ambient temperature falls below a given low temperature. The relay is connected in series with the timer switch and the thermostat to close the relay switch when both the timer switch and the thermostat are closed, whereby the pump will be operated until the timer times out or the thermostat reopens. If desired, the relay can be omitted.

Icing prevention system for a conveyor belt

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Lexington, MA, United States of America

Michael J Kaufman