Mayo Foundation for Medical Education and Research

US Government As Represented by the Secretary of the Army

Dynasil Biomedical Corporation

Michael J Joyner

Bruce D Johnson

Thomas P Olson

David R Holmes, Iii

Daniel Grant Ericson

Barry K Gilbert

Clifton R Haider

Robert W Techentin

Christopher L Felton

William A Carey

Timothy B Curry

Charlotte Sue Van Dorn

Victor A Convertino

In accordance with some embodiments, systems, methods, and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data are provided. In some embodiments, a system for estimating compensatory reserve is provided, the system comprising: a processor programmed to: receive a blood pressure waveform of a subject; generate a first sample of the blood pressure waveform with a first duration; provide the sample as input to a trained CNN that was trained using samples of the first duration from blood pressure waveforms recorded from subjects while decreasing the subject's central blood volume, each sample being associated with a compensatory reserve metric; receive, from the trained CNN, a first compensatory reserve metric based on the first sample; and cause information indicative of remaining compensatory reserve to be presented.

Systems, methods and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data

This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.

Modulating afferent signals to treat medical conditions

This document provides methods and materials for enhancing the storage capabilities of red blood cell preparations. For example, methods and materials for using COto store red blood cells in a manner that (a) reduces the level of glucose or 2,3-DPG consumption of or reduces the level of 2,3-DPG production by a red blood cell preparation, (b) reduces the level of lactate formation by a red blood cell preparation, and/or (c) reduces the pH level of a red blood cell preparation are provided. Such methods and materials can result in prolonging the useful lifespan of the red blood cells of the red blood cell preparation. This document also provides methods and materials involved in prolonging useful storage of platelet preparations. For example, methods and materials for storing platelets in a manner that reduces platelet metabolism, that preserves platelet function, and/or that reduces the risk of bacterial contamination are provided.

Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations

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Rochester, MN, United States of America

Michael J Joyner