Schering Corporation

Michael J Grace

Loretta A Bober

Jay S Fine

Daniel M Solomon

Margaret H Sherlock

Martin A Schwarz

Lee M Sullivan

Compounds of formula ##STR1## or pharmaceutically acceptable salts thereof, wherein E, Q, T, U, V, L, Z, X, W, M, Y and Y' are as set forth herein, are described. These compounds are useful as agents in the treatment of allergy, inflammation, autoimmune diseases, B-cell lymphomas, tumors, and the after effects of bone marrow transplantation.

Naphthyridines which affect IL-4 and G-CSF

A method for enhancing the immune response of a mammal to a vaccine comprising administering to such a mammal an effective amount of IL-10 in conjunction with the vaccine. A pharmaceutical composition comprised of an effective amount of IL-10, a natural, synthetic or recombinant antigen and a pharmaceutcally acceptable carrier.

Method for enhancing the antibody response to specific antigens with

Disclosed are methods of enhancing the reparative phase of wound healing and repair in a mammal by administering to the wound site during the reparative phase an effective amount of IL-4. Also disclosed are methods of enhancing the healing and repair of infected wounds, wounds of diabetic mammals, and wounds of immunocompromised mammals by administering a therapeutically effective amount of IL-4 to the wound.

Growing community of inventors

Hamilton Township, NJ, United States of America

Michael J Grace