University of Washington

Abacus Bioscience, Inc.

Other

Michael J Gale

Michael G Katze

Edward A Clark

Deborah Fuller

Che-Leung Law

Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.

Therapeutic vaccine for Hepatitis B virus (HBV) using the HBV PreS1 and/or PreS2, and/or S-HBsAg regions of the HBV envelope protein

Therapeutic vaccine for Hepatitis b virus (HBV) using the HBV PreS1 and/or PreS2, and/or s-HBsAg regions of the HBV envelope protein

The present invention relates to novel methods for identifying antiviral agents which selectively interfere with viral proteins that override the interferon(IFN)-induced cellular defense mechanisms against viral infection. In particular, the present invention relates to screening assays that identify agents which selectively inhibit the interaction between viral proteins containing an interferon sensitivity determining region (ISDR) and IFN-induced PKR protein kinase. The present invention more particularly relates to screening assays that identify agents which selectively inhibit the interaction between hepatitis C virus (HCV) nonstructural 5A protein (NS5A), which contains an ISDR, and IFN-induced PKR protein kinase. The interaction between the viral ISDR and IFN-induced PKR protein kinase results in the override of IFN-induced cellular defense mechanisms to combat viral infection. Therefore the agents identified using the assays of the invention may have utility as antiviral agents.

Screening methods to identify agents that selectively inhibit hepatitis C virus replication

Screening methods to identify agents that selectively inhibit hepatitis

A motorcycle gasoline tank filling valve including an outer member secured to an outer surface of a filling opening of a motorcycle gasoline tank. A cylindrical filling tube is slidably disposed within the outer member for communication with the motorcycle gasoline tank. A retention mechanism is secured to a lower surface of the outer member and secured to the cylindrical filling tube for biasing of the cylindrical filling tube to an orientation extended outwardly of the filling opening.

Motorcycle gasoline tank filling valve

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Monroe, WA, United States of America

Michael J Gale