Kindeva Drug Delivery, L.p.

3M Innovative Properties Company

Michael J Frits

Richard Rhys Mathias

Scott A Burton

Chin-Yee Ng

Ryan Patrick Simmers

Craig S Moeckly

Gregory R Ley

Steven P Gowers

Jerome E Gysbers

Robert G M Selby

Daniel G T Strange

Michael B Sivigny

Daniel H Berg

Richard R Mathias

A microneedle injection and infusion apparatus, and a method of using same. The apparatus can include a housing, a microneedle array holder for holding a microneedle array, and a shuttle that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.

Microneedle injection and infusion apparatus and method of using same

An applicator and method for applying a microneedle array to skin. The applicator can include a body having a first portion and a second portion defining a cavity, the second portion having a slot presented on an outside surface for insertion of the microneedle array into the cavity. The first portion and the second portion are slidable relative to one other along an axis enabling the body to be in an unprimed configuration and a primed configuration. The applicator further includes a door operable with the second portion, the door being movable from a first door position to a second door position, wherein when the device is in the unprimed configuration, the door at least partially obstructs the slot and access into the cavity. When the device is in the primed configuration, the door does not obstruct the slots and enables access into the cavity.

Applicator for applying a microneedle array to skin

An article () comprising at least one microneedle () is provided. The article comprises a first side () and a second side () opposite the first side. The first side comprises a central cavity portion () and a platform portion (), with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface (); a base segment () having a base () and a first shape; a tip segment () having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane () that delineates the base segment and the tip segment; and a central axis (). Methods of using the article are also provided.

Microneedle array and method of use

A microneedle injection and infusion apparatus, and a method of using same. The apparatus () can include a housing (), a microneedle array holder () for holding a microneedle array (), and a shuttle () that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator () movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.

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Lake Elmo, MN, United States of America

Michael J Frits