Pfizer Corporation

Michael J Fray

Kelvin Cooper

Kenneth Richardson

Alan Stobie

John Steele

Charles Eric Mowbray

Peter E Cross

David John Bull

Christopher Lee Carr

Anthony Marfat

Roger P Dickinson

Alan Daniel Brown

James F Eggler

John Paul Mathias

Andrew Simon Bell

Gavin Alistair Whitlock

Kevin Neil Dack

Peter J Whittle

Peter Thomas Stephenson

Paul Vincent Fish

Mark David Andrews

Julian Blagg

Florian Michel Wakenhut

Elisabeth Colette Louise Gautier

Mark Ian Lansdell

Mark Llewellyn Lewis

Mark Henryk Stefaniak

Alan Patrick Marchington

Melvin Cooper

A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein Ris H, Calkyl, &#x2014;C(X)Y, Ccycloalkyl, aryl, het, aryl-Calkyl or het-Calkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted by at least one substituent independently selected from Calkyl, Calkoxy, OH, halo, CF, OCF, SCF, hydroxy-Calkyl, Calkoxy-Calkyl and Calkyl-S&#x2014;Calkyl; Ris aryl or heteroaryl, each optionally substituted by at least one substituent independently selected from Calkyl, Calkoxy, OH, halo, CF, OCF, SCF, hydroxy-Calkyl, Calkoxy-Calkyl and Calkyl-S&#x2014;Calkyl; Ris Calkyl, Ccycloalkyl, Ccycloalkyl-Calkyl, aryl, het, aryl-Calkyl or het-Calkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted by at least one substituent independently selected from Calkyl, Calkoxy, OH, halo, CF, OCF, SCF, hydroxy-Calkyl, Calkoxy &#x2014;Calkyl and Calkyl-S&#x2014;Calkyl; X is S or O; Y is H, Calkyl, aryl, het, aryl-Calkyl or het-Calkyl; and n is 1 or 2, provided that when n is 1, m is 0 or 1 and when n is 2, m is 0, wherein if m is 0, then * represents a chiral center. The compounds of the invention exhibit activity as both serotonin and noradrenaline re-uptake inhibitors and therefore have utility in a variety of therapeutic areas, for example urinary incontinence.

Compounds

Compounds of formula (I):or pharmaceutically acceptable salts or solvates thereof, wherein

Quinazolinone compounds useful in therapy

Quinoxalinediones

Matrix metalloprotease inhibitors

Triazole antifungal agents

Quinoxaline derivatives useful in therapy

Quinoxalinedione NMDA receptor antagonists

A series of imidazo[4,5-c]pyridines which inhibit platelet activating factor (PAF) and also block leukotriene D4 receptors are useful in treating asthma, arthritis, psoriasis, gastrointestinal distress, myocardial infarction, stroke and shock.

Azabenzimidazoles in the treatment of asthma, arthritis and related

1,4-dihydropyridines useful as pharmaceuticals

Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R.sup.3 is lower alkyl; Y is 1,4-phenylene and X is 2-alkylimidazopyridyl.

Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters

Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl(C.sub.1 -C.sub.4)alkoxy, fluoro(C.sub.1 -C.sub.4)alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano, or is phenyl fused to a dioxole ring;

Platelet activating factor antagonists

Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R.sup.3 is lower alkyl; Y is 1,4-phenylene and X is a benzimidazol-1-yl.

Alkyl 2-benzylidene-4-(benzimidazol-1-yl) benzoylacetate esters as

Platelet activating factor antagonists of formula (I), (II) or (III): ##STR1## where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or isothiazole,

Diazepine antiallergy agents

Compounds of the formula ##STR1## where R.sup.1 is lower alkyl, R.sup.2 is chlorophenyl, Y is alkylene, X is heterocyclic and Z is a fused ring are useful as antiinflammatory and antiallergy agents.

Certain oxo-pyrrolo 1,4-dihydropyridines as antiallergy and

The invention provides compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by halo;

1,4-dihydropyridine derivatives

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Canterbury, United Kingdom

Michael J Fray