The Dow Chemical Company

Merrell Dow Pharmaceuticals

Merrell Pharmaceuticals, Inc.

Other

University of Michigan

Dendritech Inc.

Michael J Fazio

William A Fordyce

Donald A Tomalia

William Jack Kruper, Jr

Ian A Tomlinson

Larry R Wilson

David M Hedstrand

Roberta C Cheng

Michael J Mullins

Alan D Cardin

Thomas A Chamberlin

Donald A Kaplan

Douglas K Pollock

William J Kruper

James R Baker, Jr

Susan Wollowitz

Richard R Klimpel

Richard A Wolf

Muthiah N Inbasekaran

Robert D Hansen

David Scott Edwards

Anna U Bielinska

Chu W Jung

Ramaiah Muthyala

Bartley Dean Maxon

Rui Yin

Edwin J Wilson

Herbert M Brothers, Ii

Nicolas J Kotite

Jolanta F Kukowska-Latallo

Harold G Fravel, Jr

Kirk E Paisley

Muthiah N Inbaskaran

Jennifer A Johnson

Scott L Klakamp

Donald A Kaplan, Deceased

Lars T Piehler

Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.

Dense star polymer conjugates as dyes

Starburst conjugates

The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.

Narrow poly-and-mono-dispersed anionic oligomers, and their uses,

Narrow poly- and mono-dispersed anionic oligomers

Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.

Bioactive and/or targeted dendrimer conjugates

Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.

Dense star polymer conjugates

The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moities which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.

Narrow poly- and mono-dispersed anoinic oligomers, and their uses,

Narrow poly- and mono-dispersed anionic oligomers, and their uses,

A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.

Functionalized polyamine chelants and rhodium complexes thereof for

Unsaturated esters with an alkyl group at the 2 carbon, such as methyl methacrylate, react with .beta.-aminoalkanols, such as 2-aminoethanol, in the presence of an alkali metal alkoxide or hydroxide such as sodium methoxide, under moderate temperatures to form an amide such as N-(2-hydroxyethyl)methacrylamide. The amide may be cyclized by a weak Lewis acid, such as ferric chloride, at about 220.degree. C. to form a 2-alkenyl oxazoline, such as isopropenyl oxazoline.

Process for preparing 2-isopropenyl oxazoline

Hydrazone compounds having two organic moieties joined by a hydrazone group, such as phenylacetone t-butyl hydrazone, are useful blowing agents for foaming polymers, such as bisphenol A/phosgene polycarbonate at temperatures above about 280.degree. C., and particularly at about 300.degree. C. to about 310.degree. C. Polycarbonate polymers formed using the hydrazones as foaming agents show a high impact strength.

Process for foaming polymer compositions with hydrazone compounds and

The present invention is directed to a novel process for preparing isothiocyanate functionalized chelates by reacting amino functionalized chelates with thiophosgene.

Process for preparing isothiocyanato functionalized metal complexes

A group of functionalized polyamine chelants that form complexes with radioactive rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.

Functionalized polyamine chelants and radioactive rhodium complexes

The separation of coal from pyrite during a froth flotation process is enhanced by the use of an effective amount of a pyrite depressant. The depressant is a hydrophilic nitrogen-sulfur-containing compound.

Pyrite depressants useful in the separation of pyrite from coal

Growing community of inventors

Midland, MI, United States of America

Michael J Fazio