Dexcom, Inc.

Michael J Estes

Peter C Simpson

Robert James Boock

Apurv Ullas Kamath

Huashi Zhang

Kristina Lawrence

Thomas Arnold Peyser

Arturo Garcia

Stephen J Vanslyke

Jack Pryor

Sebastian Bohm

Matthew D Wightlin

Daiting Rong

Jennifer Blackwell

Sebastian Böhm

Disha B Sheth

Monica A Rixman

Anna Leigh Rack-Gomer

Aarthi Mahalingam

Leif N Bowman

Naresh Chandra Bhavaraju

Andrew Attila Pal

Lucas Bohnett

Dmytro Sokolovsky

Anna Leigh Davis

Monica Rixman Swinney

Sean T Saint

Paul V Neale

Jacob S Leach

Richard Chien Yang

Jeff Jackson

Jason Mitchell

Shanger Wang

Mark C Brister

Ryan Everett Schoonmaker

Randall Scott Koplin

Jason M Halac

Justen Deering England

Philip Thomas Pupa

Maria Noel Brown Wells

Jonathan Hughes

Phong Lieu

David DeRenzy

Todd Andrew Newhouse

Timothy Joseph Goldsmith

Eric Gobrecht

Kyle G Neuser

Leonard Darius Barbod

Stefanie Lynn Mah

Jillian K Allen

Kathleen Suzanne Hurst

Kyle Tinnell Keller

Christopher M Davis

Michael Robert Mensinger

Eli Reihman

Eric Cohen

Hari Hampapuram

Jorge Valdes

Thomas Hall

Kenneth San Vicente

Indrawati Gauba

Alexandra Lynn Carlton

Murrad Kazalbash

David S Derenzy

Ashley Hall

Alexander Steele

Kyle Neuser

Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously.

Systems and methods for processing analyte sensor data

Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

Fault discrimination and responsive processing based on data and context

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor systemis provided having a first working electrodecomprising a first sensor elementand a second working electrodecomprising a second sensor elementand a reference electrodefor providing a reference value for measuring the working electrode potential of the sensor elements

Analyte sensor

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

Devices, systems, and methods to compensate for effects of temperature on implantable sensors

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Sensors for continuous analyte monitoring, and related methods

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Polymer membranes for continuous analyte sensors

Sensors for continuous analyte monitoring

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor systemis provided having a first working electrodecomprising a first sensor elementand a second working electrodecomprising a second sensor element, and a reference electrodefor providing a reference value for measuring the working electrode potential of the sensor elements

The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing. Systems and methods according to present principles allow for such steps to occur without significant loss of spring force, and without deleterious effects such as seal slingshotting.

Transcutaneous analyte sensors, applicators therefor, and associated methods

Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously, for example, by initializing a sensor, acquiring sensor data, using the sensor, to measure an analyte level in the host's body over a first interval based on a first elapsed time since the sensor was implanted, determining whether the sensor has been previously used in a previous sensor session or the sensor is a new sensor, and upon determining the sensor is a new sensor, adjusting the acquired sensor data to compensate for sensor drift of the new sensor by applying a first set of time-dependent algorithmic functions to the sensor data associated with the first interval.

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San Diego, CA, United States of America

Michael J Estes