Synthelabo

Michael J Dimsdale

Philippe Michel Manoury

Gerard Cremer

Nigel R Beeley

New compounds of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or an alkanoyl group containing from 1 to 4 carbon atoms, R.sub.2 and R.sub.3 each represent a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, and R.sub.4 represents a hydroxy or methoxy group in the 6-position or 7-position, have been found to be useful in therapy, and more particularly in the treatment of cardiovascular diseases and Parkinson's disease.

1,2,3,4-Tetrahydronaphthalene derivatives

1,2,4-Oxadiazole derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 =H, halogen or alkyl, or two of them represent the --CH.dbd.CH--CH.dbd.CH-- group required to form a fused benzene ring and R=an amino radical NR'R' or --N.dbd.CR'.sub.3 --NR'.sub.1 R'.sub.2, in which R', R', R'.sub.1 and R'.sub.2 =alkyl, hydroxyalkyl or N,N-dialkylaminoalkyl or NRR' or NR'.sub.1 R'.sub.2 =heterocyclic ring, and R' and R' can also be H, dialkylaminoalkylcarbonyl and pyridinoalkyl, (at least two of R.sub.1 to R.sub.5 being other than H when R' and R'=H), are pharmaceutically useful as anti-hypertensive agents.

1,2,4-Oxadiazole derivatives, their preparation and pharmaceutical use

1,2,4-Oxadiazole derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 =H, halogen or alkyl, or two of them represent the --CH.dbd.CH--CH.dbd.CH-- group required to form a fused benzene ring and R=an amino radical NR'R' or --N.dbd.CR'.sub.3 --NR'.sub.1 R'.sub.2, in which R', R', R'.sub.1 and R'.sub.2 =alkyl, hydroxyalkyl or N,N-dialkylaminoalkyl or NRR' or NR'.sub.1 R'.sub.2 =heterocyclic ring, and R' R' can also be H, dialkylaminoalkylcarbonyl and pyridinoalkyl, (at least two of R.sub.1 to R.sub.5 being other than H when R' and R'=H), are pharmaceutically useful as anti-hypertensive agents.

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Villebon sur Yvette, France

Michael J Dimsdale