Ipsen Pharma S.a.s.

Radius Health, Inc.

Britannia Pharmaceuticals Limited

Michael J Dey

Nathalie Mondoly

Bart Henderson

C Richard Lyttle

Benedicte Rigaud

Jeremiah Harnett

Joel Richard

Laurent Bertocchi

Marie-Madeleine Baronnet

Zhengxin Dong

A pharmaceutical composition contains apomorphine as the active pharmaceutical ingredient, a water-miscible co-solvent, an antioxidant, and water. The solution has a pH greater than 4. The pharmaceutical composition is suitable for parenteral administration for the treatment of Parkinson's disease. The process for the manufacture of the pharmaceutical composition includes weighing the apomorphine and introducing it into a container with the co-solvent and the antioxidant under agitation until complete dissolution takes place.

Therapeutical composition containing apomorphine as active ingredient

The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) and methods of using a PTHrP and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.

Method of treating osteoporosis comprising administration of PTHrP analog

Method of drug delivery for bone anabolic protein

The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) analogue and methods of using a PTHrP analogue and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.

Stable composition comprising a PTHrP analogue

Growing community of inventors

Sandbach, United Kingdom

Michael J Dey