Ethyl Corporation

Michael J Dagani

Gunner E Nelson

Karl E Wiegand

James T Kao

A process for the preparation of alkyl 1,4-dimethyl-3-ethoxycarbonylpyrrole-2-acetate compounds by reacting a diloweralkyl acetone dicarboxylate, a chloromethyl lower alkyl ketone and an aqueous loweralkylamine in the presence of an added organic brominated or chlorinated hydrocarbon co-solvent.

Process for producing substituted pyrroles

A process for the preparation of certain 4-alkyl substituted 5-aroyl-pyrrole alkanoic acids useful as intermediates for anti-inflammatory agents.

In a process of preparing 2,2,2-trichloro-1-(N-hydrocarbylpyrryl-2)-ethanol by mixing and reacting essentially equimolar quantities of chloral and N-hydrocarbylpyrrole in a liquid reaction system containing a protonic acid added in the form of an organic acid, improvements have been made. The improvement involves (i) performing the reaction in a methylene chloride reaction medium containing protonic acid added in the form of a carboxylic acid whose acidic dissociation constant is not substantially greater than that of acetic acid, and (ii) proportioning the relative amounts of the chloral, N-hydrocarbylpyrrole and methylene chloride reaction medium so as to result in the formation of a solution of 2,2,2-trichloro-1-(N-hydrocarbylpyrryl-2)-ethanol in the reaction medium having a concentration in the range of about 1 to about 8 molar.

Acid stabilized compositions of

A process for the preparation of 1,4-dialkyl-pyrrole diesters by reacting the enamine of a dialkyl acetone dicarboxylate with a 2-hydrocarboxy-1-nitroalkane.

Bis-(imidazolylmethyl)-ether hydrochloride conversion to the corresponding amino-alkylene-thiomethyl imidazoles by reaction with amino alkylene thiols.

Conversion of ethers to thioamines

When reacting a 2,2,2-trichloro-1-(N-hydrocarbylpyrryl-2)-ethanol in solution with a cyanating reagent under basic conditions, advantages are achieved by performing the reaction in an aqueous reaction medium containing at least 3 equivalents of calcium hydroxide per mole of the 2,2,2-trichloro-1-(N-hydrocarbylpyrryl-2)-ethanol used in the reaction. Good yields are achieved in short reaction times. Large excesses of cyanating reagents are not required. It is unnecessary to add components to the reaction vessel on a periodic basis in order to achieve good yields. And it is possible to isolate the desired product in the form of a calcium salt by a facile procedure. This enables the desired product to be formed by acidification of the isolated calcium salt without the hazards of toxic HCN generation.

Synthesis of 5-cyano-1-hydrocarbylpyrrole-2-acetic acid

Synthesis of 2,2,2-trichloro-1-(N-hydrocarbonpyrryl-2)-ethanol

A process for acylating pyrrole compounds comprising reacting an aroyl halide with the pyrrole compound in the presence of an alkyl aluminum halide. Such acylated pyrrole derivatives are useful as intermediates for the preparation of anti-inflammatory agents and as synthetic intermediates.

Growing community of inventors

Baton Rouge, LA, United States of America

Michael J Dagani