The Secretary of State for Defence in Her Britannic Majesty's Government

Other

Qinetiq Limited

The Secretary of State for Defence in Her Brittanic Majesty's Government

The Secretary of State for Defence in Her Majesty's Government of the

Michael J Cook

Kenneth J Harrison

Neil Bruce McKeown

Mervyn F Daniel

Adrian J Dunn

David A Russell

Andrew J Thomson

William Guy Love

David Andrew Russell

There is provided a compound of formula (I), wherein R , R , R , R , R , R , R , R , R , X, Y , Y , Y , Z, M, A-B and C-D have meanings given in the description, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Compositions, apparatus and methods of treatment of a medical condition for which a photodynamic compound is indicated are also disclosed.

Porphyrin derivatives their use in photodynamic therapy and medical devices containing them

Phthalocyanine analogs

Susceptible tumors are treated by first sensitizing them to incident electromagnetic radiation by of a compound of the formula: ##STR1## where M is a diamagnetic metal ion or a diamagnetic metal compound or silicon or a compound of silicon or is 2H; one H being bonded to each of the two nitrogen atoms depicted as being bonded to M at positions 29 and 31;

Photosensitizers for sensitizing cells

Substituted phthalocyanines of a formula (I) ##STR1## wherein M is a metal atom or a metal halide or oxide, or M is 2H, one H being bonded to each of the bonding N atoms (29 and 31 positions) shown, R.sub.1 to R.sub.8 are the same or different and are independently selected from C.sub.1 to C.sub.20 alkyl, C.sub.1 -C.sub.20 alkenyl, --X--COO--X.sup.1, --X--O--Y, .alpha., and --X--COZ where X is independently selected from a chemical bond, (--CH.sub.2).sub.n where n=0-20 or (CH.sub.2).sub.n --CH.dbd.CH (--CH.sub.2).sub.b where a and b are independently selected from 0-20 and a+b is in the range 0-20, X.sup.1 is independently selected from C.sub.1 -C.sub.20 alkyl or C.sub.2 -C.sub.20 alkenyl, Y is independently selected from C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkenyl or H and Z is selected from OH or NR.sup.1 R.sup.11 where R.sup.1 and R.sup.11 are independently selected from H, C.sub.1 -C.sub.20 alkyl and C.sub.2 -C.sub.20 alkenyl, provided that where Y is alkyl and X is a chemical bond at least one of the groups R.sub.1 -R.sub.8 is selected from --X--COO--X.sup.1 and --X--COZ, and further provided that is R.sub.1 -R.sub.8 all contain more than 6 carbon atoms and are all selected from alkyl or --X--O--Y where X is --(CH.sub.2)--.sub.n and Y is alkyl then R.sub.1 -R.sub.8 are not all in the 2, 3, 9, 10, 16, 17, 23 and 24 positions indicated in formula I. These phthalocyanines may exhibit discotic liquid crystal phases, absorb infra-red radiation and make good Langmuir-Blodgett films.

Substituted phthalocyanines

Phthalocyanine of formula (I), wherein M is a metal or is 2H, bonded at 29 and 31 positions shown, R.sub.1 to R.sub.8 are the same or different and are independently selected from C.sub.1 to C.sub.20 alkyl, C.sub.1 -C.sub.20 alkenyl, --X--COO--X.sup.1, --X--O--Y, a, and --X--COZ where X is independently selected from a chemical bond, (CH.sub.2).sub.n where n-0-20 or (CH.sub.2).sub.a CH--CH (CH.sub.2).sub.b where a and b are independently selected from 0-20 and a+b is in the range 0-20, X.sup.1 is independently selected from C.sub.1 -C.sub.20 alkyl or C.sub.2 -C.sub.20 alkenyl, Y is independently selected from C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkenyl or H and Z is selected from OH or NR.sup.1 R.sup.11 are independently selected from H, C.sub.1 -C.sub.20 alkyl and C.sub.2 -C.sub.20 alkenyl. These phthalocyanines may exhibit discotic liquid crystal phases, absorb infra-red radiation and make good Langmuir-Blodgett films.

Growing community of inventors

Norwich, United Kingdom

Michael J Cook