Ohmx Corporation

Northwestern University

Michael J Ahrens

Paul A Bertin

Thomas J Meade

Harry B Gray

Tobin Jay Marks

Antonio Facchetti

Myung-Han Yoon

Michael R Wasielewski

Dimitra Georganopoulou

Brooks A Jones

Markus Franz Wunder

Adam G Gaustad

Amanda Eckermann

Tobin J Marks

This invention describes methods for detecting target analytes by utilizing an electroactive moiety (EAM) that functions as a substrate for a specific enzyme. If target analyte is present, a functional group is enzymatically removed from a transition metal complex resulting in quantifiable electrochemical signal at two unique potentials, Eand Ethat is detected through a self-assembled monolayer (SAM) on an electrode.

Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes

The invention relates to novel compositions of 1,3-disubstituted ferrocenes useful for the modification of electrodes.

Chemistry used in biosensors

The disclosure also relates to novel methods for detection of biological targets using amplification steps in conjunction with conversion of functional groups attached to a transitional metal complex, resulting in quantifiable electrochemical signal at two unique potentials, E&#xb0;and E&#xb0;.

Enzyme cascade methods for E-TRACE assay signal amplification

Described are methods for detecting a target analyte in a test sample by providing a solid support comprising an electrode comprising: (i) a self-assembled monolayer (SAM), (ii) a covalently attached electroactive active moiety (EAM) comprising a transition metal complex comprising a self-immolative moiety and a peroxide sensitive moiety (PSM), wherein said EAM has a first E; then contacting the target analyte and said solid support under conditions wherein said target analyte reacts with a peroxide generating enzyme to generate peroxide and said self-immolative moiety is removed such that said EAM has a second Etest sample; and then detecting said second Eas an indication of the presence of said target analyte. Also provided are compositions for use in the preceding methods.

Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay

The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.

The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, &#x3bb;, of an electron transfer process.

Electrochemical assay for the detection of enzymes

The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, &#x3bb;, of an electron transfer process.

Mono- and diimide perylene and naphthalene compounds, N- and/or core-substituted with electron-withdrawing groups, for use in the fabrication of various device structures.

N-type semiconductors and related devices

Mono- and diimide perylene and naphthalene compounds, N- and core-substituted with electron-withdrawing groups, for use in the fabrication of various device structures.

Growing community of inventors

Evanston, IL, United States of America

Michael J Ahrens