Abbvie Inc.

Xsight International

Michael J Abrahamson

David R Hill

Jianzhang Mei

Sanjay R Chemburkar

Kirill A Lukin

Russell Drew Cink

Timothy B Towne

Rajarathnam E Reddy

Angelica B Kielbus

Marvin Robert Leanna

Dennie S Welch

Gang Zhao

Richard D Bishop

Kenneth M Engstrom

Westin H Morrill

Matthew M Ravn

Matthew J Pelc

Jeff M Kallemeyn

Julie J Pruyne

John E Lallaman

William T Riordan

Gareth J Brown

Stefan Mix

Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

Enzymatic processes for the preparation of (&#xb1;)-2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid and (&#xb1;)-2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid

Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.

Process for the preparation of (S)-2-amino-non-8-enoic acid

The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

Synthetic route to anti-viral agents

The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof

Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid

Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.

Variant polypeptides capable of aminating aliphatic alpha keto acids

A fluorescent and/or phosphorescent coating composition, particularly useful as a body coating, hair coating, lipstick and particularly as a phosphorescent nail polish that has the capability of changing from transparent, or other color, in light to a phosphorescing or fluorescing composition upon the withdrawal of light. The composition, e.g., nail polish, will return to its original color, as originally perceived by a human eye, as soon as light again contacts and is absorbed by the phosphorescent or fluorescent composition. The nail polish of the present invention is capable of undergoing a reversible chemical change upon the withdrawal of light without altering its physical properties.

Body coating composition

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Chicago, IL, United States of America

Michael J Abrahamson