Siemens Industry, Inc.

University of Pennsylvania

Siemens Energy & Automation, Inc.

Michael Hogan

Thomas A Deininger

Drew Weissman

Norbert Pardi

Michael S Horn

Karen Hogan

Orkan M Telhan

Jung Min Oh

William F Raines

Yingnian Xu

John J Mautz

The present invention relates to compositions and methods for inducing an adaptive immune response against Zika virus (ZIKV) in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof. For example, in certain embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof.

Compositions for inducing an immune response against zika virus

Nucleoside-modified RNA for inducing an immune response against zika virus

A fluid transfer system includes a transfer carousel capable of rotational and/or translational movement; at least one holding vessel (e.g. syringe) having a plunger, wherein the syringe is connected to the transfer carousel such that the movement of the transfer carousel results in movement of the syringe and wherein the syringe is capable of translational movement relative to the transfer carousel; a drive motor connected to the syringe that is capable of controlling the position of the plunger; and a peripheral module comprising at least one vessel that is capable of containing a fluid, wherein the vessel has an opening that can be mated with the syringe to allow fluid transfer between the vessel and the syringe. Methods for transferring a fluid are also disclosed.

System, method, and device for high-throughput, automated culturing of genetically modified organisms

The present invention is a novel device, system, and method for runtime extension framework architecture for extending a system. According to an exemplary embodiment of the present invention, a runtime extension framework architecture may have an event manager for identifying and coordinating handling of events. The architecture may have two or more event handlers. Some event handlers may be dedicated to handling events associated with interfacing with an application program interface and some of the internal event handlers handle events as directed by the event manager.

Runtime extension framework

An extensible, object-oriented framework describes various generic elements of legacy automation systems. That framework is used as a basis for porting one or more of those elements to another ('target') automation system. Objects in the framework, known as 'extensions,' adapt information from the legacy system to a corresponding, generic representation. Compilers express those representations in the target system. The framework thus translates the &#x201c;old&#x201d; automation configuration for use in a &#x201c;new&#x201d; automation system. The scheme can be extended to accommodate arbitrary control systems (i.e., other manufacturers and product lines), new sub-domains within the automation domain (e.g. operator interfaces, batch control etc.) and new target systems without altering the core framework.

Generic framework for porting legacy process automation assets to a new control system

A system and method for creating abstract descriptions of general applications includes creating a library of code primitives and expressing skeletal code structures in terms of parametric regular tree types including parameterized declarations of the code primitives. Parametric values are generated using set comprehensions. The set comprehensions are applied to the skeletal code structures to generate a working application such that a parametric, regular object type system is combined with a comprehension syntax for creating abstract descriptions of a general application.

Parametric regular object types with comprehensions for automated generation of software test fixtures

A system and method for batch process control with diverse distributed control system (DCS) protocols is disclosed. A run-time extension acts as an adaptation layer that allows a single batch manager to supervise controllers utilizing diverse DCS protocols. The run-time extension receives commands transmitted from the batch supervisor in a first DCS protocol, translates the commands to a second DCS protocol utilized by a controller, and transmits the translated command to the controller to control various equipment associated with the controller. A database automation object (DBA) inputs configuration information from controllers utilizing diverse DCS protocols, extracts equipment information from the configuration information, generates protocol translation logic based on the configuration information, and translates recipe and formula information included in the configuration information into a common format.

System and method for batch process control with diverse distributed control system protocols

Certain exemplary embodiments can provide a computer-based translation method that translates source information into target information using knowledge that arises from relationships between elements of the source information. In certain embodiments, the computer-based method can comprise a plurality of activities comprising: obtaining information from one or more sources; applying a first plurality of pattern matching rules to the information to obtain a first transformed version of the information, the first plurality of pattern matching rules based on expert knowledge about a first plurality of patterns in the information; transforming the information using user input to obtain a second transformed version of the information, the user input obtained via a graphical user interface generated based on a second plurality of pattern matching rules, the second plurality of pattern matching rules based on expert knowledge about a second plurality of patterns in the information; and/or expressing the first transformed version and the second transformed version in a destination system.

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Schwenksville, PA, United States of America

Michael Hogan