The State University of New York

Other

The United States Government As Represented by the Department of Veterans Affairs

University of Connecticut

Paratek Pharmaceuticals, Inc.

Michael Henry Cynamon

John T Welch

Michelle S DeStefano

Michael P Draper

Dennis L Wright

S Ken Tanaka

Amy C Anderson

Leonid Heifets

Santosh Keshipeddy

Judith N Steenbergen

Eric William Scocchera

Stephanie Reeve

Michael N Lombardo

Donald W Ziemendorf

Narendran Gummudipundi Dayanandan

Daniel F Sammons

The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof.

Methods of treating mycobacterial infections using tetracycline compounds

The disclosure provides compounds of the formula I and the pharmaceutically acceptable salts thereof. The variables, e.g. R, R, R, R, A, B, J, V, W, M, J and Ar are defined herein. The disclosure also provides pharmaceutical compositions comprising a compound or salt of formula I and a pharmaceutically acceptable carrier, methods of inhibiting dihydrofolate reductase (DHFR) in vitro or in vivo with a compound or salt of formula I, and methods of treating a bacterial infections, fungal infections, and protozoal infections with a compound or salt of formula I. A compound or salt of formula I can be the first and only active ingredient used in a pharmaceutical composition or method of this disclosure or may be combined with one or more additional active ingredients that are not compounds or salts of formula I.

Zwitterionic propargyl-linked antifolates useful for treating bacterial infections

Aminomethylene amide analogs of pyrazinamide with intracellular antimycobacterial activity against pyrazinamide-resistant mycobacteria combined with a rifamycin

An apparatus for grinding specimens, comprises a container, a grinder, a closure for the container, and a seal contained in the closure. The container has an interior grinding surface and contains an opening through which specimens are introduced for grinding. The grinder has a grinding head and an actuator arm extending from the grinding head. The grinding head is adapted to engage the interior grinding surface of the container. Grinding is effected by moving the grinding head against the grinding surface, using the actuator arm. The closure is adapted to close the container and enclose the grinding head therein. The closure contains a passage through which the actuator arm extends when the closure is enclosing the grinding head. The seal is contained in the closure and coaxially aligned with the passage of the closure, such that the actuator arm slidably engages the seal when the arm passes through the closure.

Sealed grinding and homogenizing apparatus

An injection shield for protecting a person's hand during the injection of a needle into a rodent's tail. The shield comprises a frame which includes a coupler for a rodent restrainer, and contains an opening for a rodent's tail. The frame includes an injection surface on an injection side of the frame. The coupler is adapted to receive and releasably secure the restrainer in an orientation that permits the tail to be placed on the injection surface of the frame. The opening is dimensioned to allow the tail to pass through the frame, from the injection side to a shielded side. The opening is a sufficient distance from the coupler to allow the tail to extend through the opening and be grasped by the person's hand or otherwise secured. A method of protecting a person's hand during the injection of a needle into a rodent's tail is also contemplated by the present invention.

Injection shield

Compounds of formula II ##STR1## wherein R.sup.1 is a hydrocarbon, halogenated hydrocarbon, polyether, substituted phenyl, substituted benzyl or alkylamine; and R.sup.2, R.sup.3 and R.sup.4 are hydrogen, lower alkyl, halogen, haloalkyl, alkoxy and similar substituents are disclosed. The compounds are useful in the treatment of M. avium. Methods and compositions utilizing novel as well as known compounds are disclosed.

Pyrazinoic acid esters as anti-mycobacterium avium agents

Pyrazinoic esters have been prepared. Compounds of this group are effective against mycobacteria including Mycobacteria tuberculosis, pyrazinamide-resistant Mycobacteria tuberculosis, Mycobacteria bovis and Mycobacteria kansasii.

Pyrazinoic acid esters as antituberculosis agents

Growing community of inventors

Dewitt, NY, United States of America

Michael Henry Cynamon