Purdue Research Foundation

University System of Maryland

Michael Harris

Zoltan Kalman Nagy

Lynne S Taylor

James N Culver

Elcin Icten

Frederick Fiesser

Laura Hirshfield

Elizabeth Royston

Arun V Giridhar

Gintaras V Reklaitis

Kevin V Solomon

Kok Zhi Lee

Loretta Sue Loesch-Fries

Adam Brown

Yu-Hsuan Lee

Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

Methods and systems for depositing active ingredients on substrates

Methods and nucleic acid sequences for the synthesis of biotemplates in a non-plant based expression system are provided. Such biotemplates include Barley stripe mosaic virus viral-like particles (BSMV-VLPs) that are capable of self-assembly due to being operatively linked with an origin of self-assembly with the Barley stripe mosaic virus capsid protein (BSMV-CP). Also provided are BSMV-VLPs that are capable of self-assembly due one or more site-directed mutations on the BSMV-CP, and BSMV-VLPs that exhibit enhanced stability due to such site-directed mutation(s).

Nanoparticles and biotemplates with tunable length and methods of manufacturing the same

The present invention relates to high content surface areas containing nickel and/or cobalt metallic compounds assembled on a modified Tobacco mosaic virus (TMV) template, wherein the modified TMV template is engineered to encode unique placement of cysteine residues that self-assemble onto gold patterned surfaces in a substantially aligned fashion, producing a &#x3e;10 fold increase in surface area. Deposition of ionic metals onto the surface assembled virus templates produce uniform metal coatings for the fabrication of oriented high surface area materials.

Metal coated virus-based nanoelectrodes and method of assembling of same

The present invention relates to a system and method providing for increased silica growth on a bio-template, wherein the bio-template is pretreated with aniline to produce a uniform silica attractive surface and yielding a significant silica layers of at least 10 nm, and more preferably at least 20 nm in thickness, thereby providing for a high degree of stability to the bio-template.

Preparation of silica stabilized biological templates for the production of metal and layered nanoparticles

Growing community of inventors

Lafayette, IN, United States of America

Michael Harris