Axcella Health Inc.

Pronutria, Inc.

Michael Hamill

David Arthur Berry

Nathaniel Silver

Geoffrey Von Maltzahn

Raffi Afeyan

Brett Adam Boghigian

John Kramarczyk

Rajeev Chillakuru

William Comb

Chung-Wei Lee

Harry Luithardt

Sean Carroll

Ying-Ja Chen

Phillip Samayoa

Shaila Rahman

Michael Doherty

Subhayu Basu

David Young

Manu Chakravarthy

Jameson Rogers

Vimal Vaidya

Caitlyn Harvey

Kathryn Heard

David V Erbe

Matthew Russell

Joel Pradines

Karim Azer

Anthony Tramontin

Tony Tramontin

Alison Williams

Luke Hamm

Margaret Koziel

Alison Schecter

Revati Wani

Karen Lavery

This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.

Compositions and methods for the treatment of fat infiltration in muscle

This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for treating post-acute sequelae of COVID-19 comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.

Amino acid compositions and methods for the treatment of post-acute sequelae of COVID-19

This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.

Amino acid compositions and methods for the treatment of liver diseases

This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.

Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting

Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

Nutritive polypeptides and formulations thereof, and methods of production and use thereof

Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.

Charged nutritive proteins and methods

Growing community of inventors

Wellesley, MA, United States of America

Michael Hamill