Quidel Corporation

Prometheus Laboratories Inc.

Procisedx Inc.

Ortho-clinical Diagnostics, Inc

Prometheus Biosciences, Inc.

Michael Hale

Richard Laswell Egan

Jhobe Steadman

Anjali Jain

Venkateswarlu Kondragunta

William J Ferenczy

Limin Liu

Mark Ryan Mayernick

Stefan Westin

David Booker

Richard L Egan

Raj Srikrishnan

Xiaopei Huang

Hongyu Chen

Larry Mimms

Rhys De Callier

Rhys L De Callier

Mark Mayernick

A system comprised of an apparatus and a test device is described. The test device and the apparatus are designed to interact to determine the presence or absence of an analyte of interest in a sample placed on the test device. The test device and apparatus interact to provide a timer feature for determining a test device specific adjustable cut-off value that is used to ascertain whether signal from a test line in the device corresponds to a positive or negative results, irrespective of the time elapsed since placement of sample on the test device. The adjustable cut-off value renders the system relatively insensitive to incubation time of the test device, where if the incubation time is shorter or longer than needed for accuracy of a test result, the analyzer will report an invalid result, thus preventing the reporting of an incorrect (false negative or false positive) result.

Interactive test system and method for detecting an analyte

The present disclosure provides methods for assessing mucosal healing in a patient with Crohn's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

Methods for assessing mucosal healing in inflammatory bowel disease patients

An assay method for detecting the presence or amounts of VCAM-1 and A2M in a sample using fluorescence resonance energy transfer (FRET).

Assay method for the detection of VCAM-1 and alpha-2-macroglobulin in blood

Methods for assessing mucosal healing in ulcerative colitis disease patients

The present disclosure provides methods for assessing mucosal healing in a patient with Chron's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

Methods for assessing mucosal healing in Crohn's disease patients

A system comprised of an apparatus and a test device is described. The test device and the apparatus are designed to interact to determine the presence or absence of an analyte of interest in a sample placed on the test device.

System and apparatus for point-of-care diagnostics

Provided herein are analyzers as well as related methods for measuring both an absorbance and emission of a sample. The analyzer includes light sources for epi-illumination and transillumination of the sample, and detectors for measuring the intensities of excitation, emission, and transillumination light. A dichroic mirror permits a portion of the excitation light to transmit to a detector that monitors changes in excitation light intensity. Temperature sensors allow for signal corrections based on temperature variations of the detectors and sample.

Analyzer

Interactive test device and apparatus with timing mechanism

Growing community of inventors

San Diego, CA, United States of America

Michael Hale