William Marsh Rice University

Universitat Leipzig

Michael Hacker

Antonios Georgios Mikos

Christina Dieckmann

Michaela Schulz-Siegmund

Vuk Savkovic

Jan-Christoph Simon

The present invention relates to the field of biology and medicine, and more specifically, to the field of stem-cell biology, involving producing or generating melanocytes from stem-cells and precursors derived from human hair root. Additionally, the present invention relates to the materials and method for producing autografts, homografts or allografts comprising melanocytes in general, as well as the materials and methods for producing autografts, homografts and allografts comprising melanocytes for the treatment of diseases related to depigmentation of the skin and for the treatment of scars.

Method for deriving melanocytes from the hair follicle outer root sheath and preparation for grafting

Macromonomers capable of both physical crosslinking and chemical crosslinking. The combination of chemical crosslinking and physical crosslinking provides the ability to generate rapidly gelling hydrogels for many different applications. Moreover, the macromonomers may incorporate functional groups that allow for two different gelation mechanisms&#x2014;thermal gelation and ionic gelation&#x2014;further improving mechanical stability of hydrogels formed from the disclosed macromonomers.

Macromonomers and hydrogels

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Leipzig, Germany

Michael Hacker