Hewlett-packard Company

Agilent Technologies, Inc.

Caliper Life Sciences, Inc.

Other

Pelikan Technologies, Inc.

Applied Biosystems, LLC

Peliken Technologies, Inc.

Fujifilm Corporation

Wako Pure Chemical Industries, Inc.

Michael Greenstein

Paul K Lum

Dominique M Freeman

Hewlett E Melton, Jr

Tad Decatur Simons

Edward D Verdonk

Leslie Anne Leonard

David A King

Ganapati R Mauze

Colin B Kennedy

Mir S Seyed-Bolorforosh

King-Wah W Yeung

Rick Pittaro

Dirk Boecker

Robert Andrew Howard

Stephan Bianchi

Huan L Phan

Turuvekere R Gururaja

Jonathan R Harris

Andrew Zee

Michael C Higgins

Catherine Keely-Templin

Daren Walter Hebold

James C Mikkelsen, Jr

Henry Yoshida

Don Alden

Robert S Dubrow

Luc J Bousse

Frank W Ingle

Aaron J Rulison

Richard D Pering

Vladimir J Drbal

Persefoni E Kechagia

Khushroo Gandhi

Frederick A Stawitcke

Olaf Soerensen

Chirag Patel

Klaus Stefan Drese

Jerry Zawadzki

Ed Donlon

Hans-Joachim Hartmann

Bruce Brogden

Hans Fuernkranz

Belinda Kendle

Belinda J Kendle

Masayoshi Hayashi

Hiroshi Yada

Masakuzu Sugimoto

Douglas Harriott

Ed Verdonk

Jim C Mikkelsen

Andrew L Zee

Daren W Hebold

Youichi Endo

Shinji Satomura

Mitsuo Watanabe

Cheryl Cathey

Yoshihiro Seto

A genetic surveillance system comprises a communications network and at least one reader-analyzer instrument. The reader-analyzer instrument has a communication interface to communicate over the network. The reader-analyzer instrument is adapted to perform genetic assay analysis of a sample obtained from a member of a population and to generate detection-related data based upon the analysis. The reader-analyzer instrument is adapted to associate qualifying information with the detection-related data and to communicate the associated qualifying information and detection-related data over the network.

System for genetic surveillance and analysis

The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.

Automated system for handling microfluidic devices

An apparatus having a shaft that can sense the depth of penetration, for penetrating into an object (the substrate). The substrate being penetrated has impedance that varies according to the depth under a surface of the substrate. The shaft has a tip for penetration and has conductive ends near to the tip of the shaft. A change of impedance of material of the object between the conductive ends can be sensed to provide information on the depth of penetration. A processor can be provided external to the object being penetrated by the shaft to gather and process the impedance information to determine whether the desired depth has been achieved.

Apparatus and method for penetration with shaft having a sensor for sensing penetration depth

A cassette containing cartridges for sampling blood from a patient. The cassette includes a container for storing a plurality of cartridges and at least one cartridge in the container. The cartridge includes a cartridge case and a lancet. The lancet has a tip and is housed in the cartridge case. The lancet can be driven to extend the tip outside the cartridge case for lancing the skin of the patient to yield blood. The container has a compartment that contains at least one cartridge. A cartridge from the compartment can be loaded onto a glucometer that drives the lancet in the cartridge to lance the skin of a patient.

Cassette of lancet cartridges for sampling blood

A portable medical analyzer comprising a sampling module with a sample port for receiving body fluid, an assay sensor module for analysis of the body fluid, an analytical detector module with detection of information from the assay, and a communications module for transferring the information to a remote location via a wired or wireless network.

Universal diagnostic platform

This invention provides methods and systems for flushing, washing, and priming microscale devices for reuse. Washing and priming methods include flowing solutions from a manifold to flush wells and microchannels of a microfluidic chip. Systems include manifolds adapted to seal and flow solutions or gasses into chip wells. Devices include microfluidic devices with data storage modules to track the reprocessing status of the microscale devices.

Methods and systems for processing microscale devices for reuse

A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes ('LED's) and vertical cavity surface emitting lasers ('VCSEL's), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.

Thermal regulation of fluidic samples within a diagnostic cartridge

Methods and apparatus for delivering fluidic materials to sample destinations, including mass spectrometers for analysis are provided. In preferred embodiments, sample aliquots are electrosprayed from tapered spray tips of capillary elements into the orifices of mass spectrometric inlet systems. In certain embodiments, fluidic samples are orthogonally sprayed from capillary elements or other fluid conduits, whereas in other embodiments samples are sprayed after devices are rotated or otherwise translocated from sample sources to sample destinations. In still other embodiments, samples are sprayed from flexed or deflected capillary elements at selected sample destinations.

Microfluidic sample delivery devices, systems, and methods

A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic 'sipper' chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.

Container providing a controlled hydrated environment

A device for puncturing the skin of a patient. The device includes first and second protrusions, each protrusion puncturing the skin when pressed against the skin. The first and second protrusions are arranged such that the first protrusion punctures the skin at a location less than a predetermined distance from the second protrusion. The distance is chosen to be less than the discriminatable distance between distinct pain perception points in the patient, such that the patient perceives a single puncture when the first and second protrusions puncture the skin. In one embodiment of the invention, the device includes a base lip that applies a lateral force to the skin when the base lip is pressed against the skin. In this embodiment, the protrusions are pressed into the skin as the base lip is pressed against the skin.

Multiple lancet device

Method of using cassette of lancet cartridges for sampling blood

Growing community of inventors

Los Altos, CA, United States of America

Michael Greenstein