Functional Genetics, Inc.

Other

University of Central Florida Research Foundation, Inc.

Eli Lilly and Company

Michael Goldblatt

Michael Scott Kinch

Roxanne Duan

Peter J Delfyett

Limin Li

Wu-Bo Li

Nazanin Hoghooghi

Ke Weng

Heather Thi Thu Ung-Medoff

Hanwen Mao

Manu Kohli

Zenbework Fesseha

Huosheng Chen

Shaojing Chang

Douty Bamba

Josue Davila-Rodriguez

Apparatuses and methods for modulating an optical signal are disclosed. One embodiment is a method comprising: phase modulating a slave laser which is injection locked to a master laser to produce an arcsine phase modulated optical signal, and combining the arcsine phase modulated optical signal with an output optical signal from the master laser.

Optical modulator with linear response

A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL)-PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail.

Methods of inhibiting HIV infectivity

The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume.

Random homozygous gene perturbation to enhance antibody production

A method of inhibiting viral respiratory infection in a mammal in need of same, includes administering an effective amount of 2-[2-(5-carbamimidoyl-benzofuran-2-yl)-vinyl]-H-benzoimidazole-5-carboxamidine or the Bis-N-hydroxyamidine prodrug thereof, prior to viral infection, or therapeutically following viral infection, to inhibit that viral infection. The compound selectively inhibits Caspase 2 and/or 8 as to prevent infective viral particle release. It is optionally administered IV, IP, orally or via other conventional administration routes in a dosage range of 1 ng/kg-200 mg/kg of body weight.

Methods of inhibiting viral infection

The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg 101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.

Therapeutic targeting of escort proteins

The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection.

Anti-TSG101 antibodies and their uses for treatment of viral infections

Growing community of inventors

McLean, VA, United States of America

Michael Goldblatt