Cardiac Pacemakers, Inc.

Musc Foundation for Research Development

Michael Gold

Yinghong Yu

Dan Li

Shibaji Shome

Francis G Spinale

Rupak Mukherjee

Jagmeet Singh

A system comprises a cardiac signal sensing circuit and a processor circuit. The cardiac signal sensing circuit is configured to sense a cardiac signal segment using a set of electrodes connectable to the cardiac signal sensing circuit. The processor circuit is communicatively coupled to the cardiac signal sensing circuit and includes a peak detector circuit. The peak detector circuit is configured to identify, in the cardiac signal segment, a fiducial indicative of ventricular activation that is local to at least one electrode of the first set of electrodes. The fiducial includes a first large positive or negative peak greater than a specified percentage of a maximum peak of the first cardiac signal segment. The processor circuit is configured to provide an indication of local ventricular activation to at least one of a user or process.

Apparatuses and methods using the role of ventricular electrical delay to predict left ventricular remodeling with cardiac resynchronization therapy

Disclosed herein are methods of and systems for predicting recurrence of atrial fibrillation comprising protease and protease inhibitor profiling. The levels of matrix metalloproteinases (MMPs) and/or tissue inhibitor metalloproteinases (TIMPs) are analyzed to predict the recurrence of atrial fibrillation, and further to predict whether cardioversion will provide a successful therapy.

Predicting atrial fibrillation recurrence by protease and protease inhibitor profiling

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Daniel Island, SC, United States of America

Michael Gold