Johns Hopkins University

Medimmune Limited

Michael Glen Overstreet

Lieping Chen

Solomon Langermann

Linda Liu

Sheng Yao

Anti-human B7-H4 antibody '6H3', antigen-binding fragments, derivatives, and humanized variants thereof that are capable of immunospecifically binding to B7-H4, and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases are disclosed. In preferred embodiments, the molecules are used to retard or prevent tumor growth, inhibit tumor-mediated suppression, eliminate tumors and/or deplete or block the activity of tumor-associated macrophages ('TAMs') so as to alter their activity and/or decrease TAM-mediated immune suppression.

Growing community of inventors

Crownsville, MD, United States of America

Michael Glen Overstreet