Actelion Pharmaceuticals Ltd

Ucb Pharma, S.a.

Oxford Glycosciences (uk) Ltd

The Chancellor, Masters and Scholars of the University of Oxford

Michael Glen Orchard

Judi Charlotte Neuss

Andrew Carr

David William Porter

Raymond A Dwek

Frances M Platt

Mezher Hussein Ali

George W J Fleet

Terence D Butters

David Ian Carter Scopes

Carl Maurice Swedler Galley

David Ian Scopes

Mark William Pennington

Frances Mary Platt

George Fleet

David Ian C Mandalay Scopes

Pharmaceutically active piperidine derivatives

The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.

Substituted aniline derivatives

The present invention provides novel piperidine derivatives of formula (I), 

2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide

The present invention relates to the compound 3,4,5-piperidinetriol, 2-(hydroxymethyl)-1-[(4-(pentyloxy)phenyl)methyl]-, (2S,3S,4R,5S), or a pharmaceutically acceptable salt or prodrug thereof, which is useful as an inhibitor of glucosylceramide synthase. The compounds of the Invention are useful for treating various glycolipid storage diseases, such as Gaucher's disease, Sandhoff's disease, Tay-Sacs disease, Fabry disease, and GM1 gangliosidosis; glycolipid accumulation disorders, such as Niemann-Pick disease, mucopolysaccharidoses, mucolipidosis type IV and &#x3b1;-mannosidosis; various cancers that involve abnormal glycolipid synthesis; and various infectious diseases that involve cell surface glycolipids as receptors for the infectious organisms or for their toxins; as well as a variety of other disorders involving glycolipid synthesis, including neuronal disorders, inflammatory diseases, obesity, and the like.

2-hydroxymethy1-3,4,5-trihydroxy-1-(4-pentyloxybenzyl) piperidine as glucosylceramide synthase (Gcs) inhibitor

Compounds of formula (I); wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase. 

Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase

Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase. 

Piperidinetriol derivatives as inhibitors of glycosyceramid synthase

A compound of formula I or a salt thereof wherein, A is O or S, X and Y independently represent O, CHand may be the same or different, Q is (CH)&#x2014;CH(R1)-(CH), R is OR6, NHR8, R1 is hydrogen, or optionally substituted alkyl, R2 and R3 are independently hydrogen, or specific substituents, provided that R2 and R3 are not both H, and R4 and R5 are hydrogen or specific substituents, m is 0&#x2013;3; n is 0&#x2013;2; are useful in the treatment of fungal infections.

Benzylidene thiazolidinediones and their use as antimycotic agents

Compounds of formula (I) or salts thereof are provided wherein X is O or S, A and B are OR2 or Y&mdash;NR3R4 wherein when A is OR2. B is Y&mdash;NR3R4 and vice versa, or when one of A or B is OR2. then the other can be CO R7. Y is CH or C&boxH;Q. Q is (CH ) &mdash;CH(R1)&mdash;(CH ) , R is OR6 or NHR7 and with the other definitions as set out in claim 1, a process for its preparation and its use in the prophylaxis or treatment of fungal infections.

Thiazolidine derivatives and its use as antifungal agent

The present invention relates to quinolinium- and pyridinium-based fluorescent dyes. The dyes are useful for staining proteins in solution, in gels and on solid supports. The dyes of the invention exhibit higher fluorescence emission than known compounds when bound to proteins and also exhibit improved contrast of fluorescence intensity between their protein-bound and unbound states.

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Oxfordshire, United Kingdom

Michael Glen Orchard