Gx Biosystems A/s

Danmarks Tekniske Universitet

Unisearch Limited

Benzon Pharma, A/s

Michael Givskov

Soren Molin

Leo Eberl

Claus Sternberg Kristensen

Asim K Bej

Thomas Ostenfeld Larsen

Thomas Bjarnsholt

Peter David Steinberg

Peter Canisius De Nys

Staffan Kjelleberg

Niels Høiby

Erik Riise

Ria Maximilien

Michael Manefield

Lone Gram

David Tanner

Tim Holm Jakobsen

Louise Dahl Hultqvist

Maria Alhede

Meenakshi Sundaram Shanmugham

Richard Phipps

Peter Østrup Jensen

Peter ØStrup Jensen

Maria Van Gennip

Louise Dahl Christensen

The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C&#x2550;C&#x2014; bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

Process for the manufacture of ajoene derivatives

A method and microbial culture medium for inhibiting homoserine lactone and/or acylated homoserine lactone regulated processes in microorganisms using furanone compounds.

Methods for microbial regulation

The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations of cells containing, in addition to such a regulatably expressible gene, a DNA coding for an immunologically active, pesticidally active or environmental pollutant-degrading gene product, may be useful in immunologically active compositions, pesticidally active compositions and environmental pollutant-degrading compositions, respectively.

Method of limiting the survival of genetically engineered microorganisms

The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations of cells containing, in addition to such a regulatably expressible gene, a DNA coding for a pesticidally active or environmental pollutant-degrading gene product, may be useful in pesticidally active compositions and environmental pollutant-degrading compositions, respectively.

Extracellular Serratia spp. enzymes have been found to be excreted by another gram-negative organism harbouring a plasmid carrying DNA from Serratia spp. encoding the enzymes. This organism, e.g. E. coli, is therefore employed to produce the enzymes, specific examples of Serratia spp. enzymes produced are a nuclease, a lipase and a phosopholipase. The nuclease may be employed to remove nucleic acids from a biological material.

Production in Escherichia coli of extracellular Serratia spp. hydrolases

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Copenhagen, Denmark

Michael Givskov