Juno Therapeutics Gmbh

Michael Gerard Covington

Jeff D Smith

Mark J Gilbert

He Li

Christopher Glen Ramsborg

Pascal Beauchesne

Ryan P Larson

Claire L Sutherland

Clinton Weber

Valerie Odegard

Kathryn Lindsay Pollock

Tom Kowski

Brian Christin

Nathan K Yee

Andrew W Walker

Mary Mallaney

Kedar Himanshu Dave

Richard James Getto, Jr

James Boyd Whitmore

Travis Beckett

Samuel Charles Blackman

Nathaniel Chartrand

Nathaniel Lambert

Mel Davis-pickett

Nikolaus Sebastian Trede

Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.

Determining toxicity risk in CAR T-cell therapy

Growing community of inventors

Seattle, WA, United States of America

Michael Gerard Covington