Technische Universitaet Ilmenau

Universitaetsklinikum Jena

Technische Universitat Ilmenau

Universitatsklinikum Jena

Michael Gebinoga

Andreas Schober

Frank Weise

Uta Fernekorn

Gregor Schlingloff

Joerg Hampl

Angelika Mueller

Justyna Borowiec

Astrid Voigt

Sukhdeep Singh

Jörg Hampl

Julia Katzmann

Sebastian Haefner

Thomas Klar

James Beck

Sebastian HÄFNER

Astrid Schaeffer

Angelika MÜLLER

The present invention relates firstly to a method for reproducing a stem cell niche of an organism. The invention further relates to a reproduction of a stem cell niche of an organism. According to the invention, an image of a tissue of an organism is generated, which tissue comprises at least one stem cell niche. The image is filtered in order to obtain a structural pattern of the imaged stem cell niche. In a further step, a lithographic mask is generated from the structural pattern. According to the invention, a starting material of a substrate is structured by means of indirect or direct application of the lithographic mask, whereby a structured substrate is obtained which represents the reproduction of the imaged stem cell niche of the organism. The reproduction can be characterised as biolithomorphic.

Reproduction of a stem cell niche of an organism and method for the generation thereof

The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.

Structure modeled on a biological tissue and method for producing said structure

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Ilmenau, Germany

Michael Gebinoga