Alza Corporation

Michael G Zuck

Joseph Creagan Trautman

Hyunok Lynn Kim

Peter E Daddona

Michel J Cormier

Patrick S-l Wong

A device (,) comprising a sheet member (,) having a plurality of microprotrusions (,) for penetrating the skin and a rigid support (,) contacting and extending across the sheet member (,) for transmitting an applied force evenly across the length and width of the sheet member (,) to reproducibly and reliably penetrate the skin with the microprotrusions (,).

Device for enhancing transdermal agent flux

A device (3) comprising a sheet member (6) having a plurality of microprotrusions (4) for penetrating the skin and a substantially incompressible agent reservoir housing (15) contacting and extending across the sheet member (6) for transmitting a hold-down force applied the sheet member (6) to maintain the microprotrusions (4) in skin-piercing relation to the skin, even during and after normal patient body movement.

A device (2) comprising a sheet member (6) having a plurality of microprotrusions (4) extending from a bottom edge (5) for penetrating the skin of a patient. The sheet member (6) when in use being oriented in an approximately perpendicular relation to the patient's skin.

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Bend, OR, United States of America

Michael G Zuck