Princeton University

University Technologies International, Inc.

Other

Quorex Pharmaceuticals, Inc.

Mcmaster University

Michael G Surette

Bonnie L Bassler

Kevan M Shokat

Stephan Schauder

Jeffrey D Stein

Carol Dammel

Gerard Wright

Hendrik Poinar

Andrew Mcarthur

Allison Guitor

The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.

Compounds and methods for regulating bacterial growth and pathogenesis

The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.

Compositions and methods for regulating bacterial pathogenesis

This invention provides a purified extracellular bacterial autoinducer- signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides is a new class of bacterial genes involved in the biosynthesis of the signaling molecule.

Growing community of inventors

Calgary, Canada

Michael G Surette