Virobay, Inc.

Syntex (u.s.a.) Inc.

Michael G Roepel

John O Link

Michael Graupe

David Bernard Smith

Todd Richard Elworthy

Keith Adrian Walker

Denis John Kertesz

Eduardo Setti

Barry Patrick Hart

Tara Mirzadegan

Michael Green

The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

Alpha ketoamide compounds as cysteine protease inhibitors

This invention relates to compounds which are generally EPreceptor agonists and which are represented by Formula I:wherein A is a &#x2014;CH&#x2014;CH&#x2014;, or &#x2014;CH&#x2550;CH&#x2014;; B is absent, an aryl, or heteroaryl group; Ris alkyl, alkenyl, alkynyl, cycloalkylalkyl, heterocyclylalkyl, aryl, arylalkyl or heteroaryl, when B is aryl or heteroaryl and R, R, Rand Rare not simultaneously hydrogen, or Ris heterocyclylalkyl, aryl, or heteroaryl when B is absent and R, R, Rand Rare simultaneously hydrogen; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

8-aza-11-deoxy prostaglandin analogues

This invention relates to 8-aza prostanoid analogs which are generally EPreceptor agonists and are represented by Formula I:wherein Q, B, X, J, Z, A and R-Rare as defined, their synthesis and use for treatment of osteoporosis and increasing bone density.

2-pyrrolidone derivatives as prostanoid agonists

This invention relates to certain 2,4-substituted pyrrolidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists

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San Francisco, CA, United States of America

Michael G Roepel