American Cyanamid Company

Other

Michael G Lanzilotti

James R Lawter

Nancy S Brizzolara

Krzysztof Appelt

A method to prepare a catheter locking formulation, comprising in a first step, dissolving trimethoprim in propylene glycol at a temperature greater than room temperature, and in a final step, adding absolute ethanol at about room temperature to a solution of trimethoprim, propylene glycol, EDTA Calcium Disodium Hydrate, phosphate buffered saline, and glycerin.

Catheter locking formulation and method to prepare same

Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits.

Method for the treatment of periodontal disease by sustained delivery of

Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer of preferably, the dry microparticles and dispersed into the periodontal pocket whereby upon contact with the moist environment of the pocket, they hydrate, become tacky and adhere to one another and to the tissues surrounding the pocket so as to maintain intimate contact with the involved tissue so as to induce long term therapeutic benefits.

Phase separation-microencapsulated pharmaceuticals compositions useful

Apparatus for the treatment of periodontal disease

There is disclosed a process for preparing compositions comprising microcapsules by phase separation microencapsulation wherein the hardening agent employed is a volatile silicone fluid and with the compositions prepared thereby. The use of the volatile silicone fluid as a hardening agent permits the production of microcapsules substantially free of any alkane hardening agent, eliminating potential combustability problems of the prior art processes and toxicity problems of the prior art compositions.

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Pearl River, NY, United States of America

Michael G Lanzilotti