Wyeth

American Home Products Corporation

Amgen Inc.

Renovis, Inc.

Evotec Ag

Evotec (us) Inc.

Second Genome, Inc.

Evotec Inc.

Michael G Kelly

Wayne Everett Childers

John Kincaid

Yvette L Palmer

Ping Zhou

Ning Xi

Derek Cecil Cole

Carl J Kaub

Shimin Xu

Sharon J Rosenzweig-Lipson

Christopher Harold Fotsch

Gan Zhang

Thomas Stephen Coulter

Yunfeng Fang

Lynne Padilla Greenblatt

Satyanarayana Janagani

Chiara Ghiron

Zhi-Liang Wei

Young H Kang

Mark Henry Norman

Guoxian Wu

Zhan Wang

Edward J Podlesny

Yeyu Cao

Sumithra Gowlugari

Philip Miller

Lee Erwin Schechter

Carl Kaub

Ning Chen

Matthew Duncton

Elizabeth M Doherty

John F Kincaid

Qingyian Liu

Nuria A Tamayo

Paul E Harrington

Frances Christy Nelson

Nianhe Han

Donogh John Roger O'Mahony

Yunxin Y Bo

Ravindra B Upasani

Byron Abel Bravo

Jianhua He, Legal Representative

David Lonergan

Duncan M Smith

David J Semin

Boyd Lynn Harrison

Andrew Stewart Tasker

Annmarie Louise Sabb

Xianghong Wang

Markian Myroslaw Stec

Andrew A Welcher

Gilbert M Rishton

Michael D Croghan

Robert L Vogel

William Jospeh Lennox

Jiawang Zhu

Vassil I Ognyanov

David Joseph St Jean, Jr

Steven Edward Lenicek

Partha P Chakrabarti

Duanzhi Wen

Yanfang Li

Steve Fong Poon

Matthew Alexander James Duncton

Premilla Arasasingham

Martin H Goldberg

Reinhartd B Baudy

Kiran Sahasrabudhe

Stacey J Sukoff Rizzo

Robert Townsend

Adam James Davenport

Feng-Yin Hsieh

Qing Ping Zeng

David Scott Nunn

William Joseph Lennox

David J St Jean, Jr

Donogh O'MAHONY

Thomas S Coulter

Thomas Coutler

Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds are disclosed that have formula 1: where A, B, L, N, R, R, R, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, respiratory conditions, and others.

Tetrahydronaphthyridine and tetrahydropyrido[4,3-D]pyrimidine compounds and compositions thereof useful for the treatment of inflammatory and respiratory diseases

Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Bicycloheteroaryl compounds as P2X7 modulators and uses thereof

Fused heterocyclic compounds are provided according to formula 1a or 1b:  where R, R, and Rare as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof

[object Object]

The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes. 

Calcium receptor modulating agents

The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula I. 

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Fused heterocyclic compounds are provided according to formula 1: where R, R, R, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof

Novel piperazine derivatives are provided having the formula wherein Ris cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HTreceptor antagonists.

Serotonergic agents

The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.

Interferon-like molecules and uses thereof

Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R, R, R, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Vanilloid receptor ligands and their use in treatments

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Growing community of inventors

Thousand Oaks, CA, United States of America

Michael G Kelly