California Institute of Technology

University of California

Occidental College

Michael G Hill

Jacqueline K Barton

Shana O Kelley

Brian Jet-Fei Wong

Dmitry E Protsenko

Bryan M Hunter

Andrew Udit

Elizabeth M Boon

Wesley Moy

Joon S You

Max L Weaver

Ariel L Furst

John L Cuha

Natalie B Muren

A method of altering adipose tissue includes creating an electrochemical reaction in the tissue, wherein the electrochemical reaction occurs in the presence of an electrolytic solution in the tissue.

Method and apparatus to electrochemically treat adipose tissue in the human body

A method of modifying a tissue includes providing an electrochemical reaction in the tissue by the use of an anodic electrode and a cathodic electrode wherein at least one of the anodic and cathodic electrodes is in contact with the tissue; and setting a concentration of electrochemically generated chemical agents that affect the tissue.

Potential driven electrochemical modification of tissue

A two-electrode detection system having target substrates including nucleic acids, proteins, and/or small molecules on specifically defined regions of a single surface. The spatial distribution of the target substrate on the surface allows for more accurate substrate interactions and analysis. Additionally, the detection system of the present invention allows for patterning of different target substrates, thereby affording more accurate analysis of multiple substrate targets.

Electrochemical substrate patterning and analyte detection on a two-electrode platform

Described herein are methods, compositions and kits utilizing heterogeneous metal catalysts for the preparation of cycloaddition compounds, such as triazoles and biomolecules.

Methods, compositions, and kits using heterogeneous catalysts

The present invention relates to the use of electrochemistry to control and generate specific user defined chemical reactions in regions that may be defined by electrode placement and geometry. In one embodiment, the present invention provides a method of shape changing cartilage in a subject through potential-driven electrochemical modification of tissue (PDEMT) or use of a potential-driven electromechanical (EMR) device.

Compositions and methods for electrochemical detection and localization of genetic point mutations, common DNA lesions and other base-stacking perturbations within oligonucleotide duplexes adsorbed onto electrodes and their use in biosensing technologies are described. An intercalative, redox-active moiety (such as an intercalator or nucleic acid-binding protein) is adhered and/or crosslinked to immobilized DNA duplexes at different separations from an electrode and probed electrochemically in the presence or absence of a non-intercalative, redox-active moiety. Interruptions in DNA-mediated electron-transfer caused by base-stacking perturbations, such as mutations or binding of a protein to its recognition site are reflected in a difference in electrical current, charge and/or potential.

Electrochemical sensor using intercalative, redox-active moieties

Compositions and methods for electrochemical detection and localization of genetic point mutations and other base-stacking perturbations within oligonucleotide duplexes adsorbed onto electrodes and their use in biosensing technologies are described. An intercalative, redox-active moiety (such as an intercalator or nucleic acid-binding protein) is adhered and/or crosslinked to immobilized DNA duplexes at different separations from an electrode and probed electrochemically in the presence or absence of a non-intercalative, redox-active moiety. Interruptions in DNA-mediated electron-transfer caused by base-stacking perturbations, such as mutations or binding of a protein to its recognition site are reflected in a difference in electrical current, charge and/or potential.

Growing community of inventors

Pasadena, CA, United States of America

Michael G Hill