The Secretary of State for Defence in Her Brittanic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland

Michael G Drew

Paul D Beer

Graeme Peter Nicholson

Mark Joseph Kan

Gareth Williams

Disclosed are &ldquo;acid-amide&rdquo; calixarenes of formula (I) wherein: L is &lsqb;&mdash;CH &mdash;&rsqb; or &lsqb;&mdash;O&mdash;CH &mdash;O&mdash;&rsqb; and may be the same or different between each aryl group R is H, halogen, or C aliphatic hydrocarbyl group, C aryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R may be the same or different on each aryl group; R comprises an optionally protected carboxy group; two groups out of R , R , and R , are H; the one group out of R , R , and R not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers

Calixarenes and their use for sequestration of metals

Disclosed are &ldquo;acid-amide&rdquo; calixarenes of formula (I) wherein: L is &lsqb;&mdash;CH,&mdash;&rsqb; or &lsqb;&mdash;O&mdash;CH,&mdash;O&mdash;&rsqb; and may be the same or different between each aryl group; R,is H, halogen, or C,C,aliphatic hydrocarbyl group, C,C,aryl group, C,C,hydrocarbyaryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R,may be the same or different on each aryl group; R,comprises an optionally protected carboxy group; two groups out of R,, R,, and R,are H; the one group out of R,, R,, and R,not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers.

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Reading, United Kingdom

Michael G Drew