Eli Lilly and Company

Michael Funk Chiappetta

William Godwin Atterbury

Jeffrey L Ellis

David Arthur Holley

Mark Lafever

Corrie Bennison

Beverly Anne Piatt

John Paul Tallarico

Beverly Ann Piatt

Robert Jonathan Cain

Processes and devices provide parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. A device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.

Processes and devices for delivery of fluid by chemical reaction

Growing community of inventors

Greenwood, IN, United States of America

Michael Funk Chiappetta