Genentech, Inc.

Michael Fung

Cecily R Y Sun

William N C Sun

Meisheng Lu

The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated by excessive or uncontrolled production of C5a. The inhibitor molecules are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.

Nucleic acids encoding antibody 137-26 which binds C5 and C5a

The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab')and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.

Methods of inhibiting alternative pathway complement activation with anti-factor D antibodies

Anti-C5/C5a antibodies and methods of use

The invention relates to inhibitors that bind to C5 and C5, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, which binds to a shared epitope of human C5 and C5. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated by excessive or uncontrolled production of C5. The inhibitor molecules are also useful for diagnostic detection of the presence/absence or amount of C5 or C5

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Gaithersburg, MD, United States of America

Michael Fung