Rules-Based Medicine, Inc.

Specifica Inc.

Other

The University of New Mexico

Michael Frank Erasmus

Andrew Raymon Morton Bradbury

Andre Teixeira

Michael D Horowitz

Stuart S Winter

Bridget S Wilson

Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Antibody libraries with maximized antibody developability characteristics

This disclosure describes the identification of pre-B Cell Receptor (pre-BCR) antagonists and the use of pre-BCR antagonists as a targeted therapy. The compositions and methods generally involve a composition that includes a pre-B cell receptor (pre-BCR) antagonist and is engineered for expression as a T cell chimeric receptor. In some embodiments, the pre-BCR antagonists can include an anti-pre-BCR antibody.

Anti-pre-BCR antagonists and methods

Growing community of inventors

Santa Fe, NM, United States of America

Michael Frank Erasmus